The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection

被引：19
作者：
Cheyuo, Cletus [1 ,2 ,3 ]
Yang, Weng-Lang [1 ,3 ]
Wang, Ping [1 ,2 ,3 ]
机构：
[1] N Shore LI Jewish Hlth Syst, Ctr Immunol & Inflammat, Feinstein Inst Med Res, Manhasset, NY 11030 USA
[2] Elmezzi Grad Sch Mol Med, Manhasset, NY 11030 USA
[3] Hofstra N Shore LIJ Sch Med, Dept Surg, Manhasset, NY 11030 USA
来源：
BIOLOGICAL CHEMISTRY | 2012年 / 393卷 / 06期
关键词：
adrenomedullin; AMBP-1; apoptosis; inflammation; neurodegenerative disease; neuroprotection; COMPLEMENT FACTOR-H; BLOOD-BRAIN-BARRIER; CEREBRAL ENDOTHELIAL-CELLS; RECEPTOR-LIKE RECEPTOR; GENE-RELATED PEPTIDE; MESSENGER-RNAS; MODIFYING PROTEINS; OXIDATIVE STRESS; EPITHELIAL-CELLS; HUMAN ASTROCYTES;
D O I：
10.1515/hsz-2012-0103
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chronic neurodegenerative disorders and acute injuries of the central nervous system exert a prohibitive economic burden, which is aggravated by an unmet medical need for the development of effective neurotherapeutics. The evolutionarily conserved neuropeptide, adrenomedullin (AM), and its binding protein, AMBP-1, also known as complement factor H, play important roles in brain physiology, and their expression is altered in brain pathology. In this review, we discuss the molecular regulation of AM and AMBP-1 and the pivotal roles they play in neuroprotection following brain injury. We assess the reciprocal synergistic effects of AM and AMBP-1 and make suggestions for the design of a novel combination neurotherapy devoid of the potential hypotensive effects of AM while optimizing its neuroprotective property.
引用
收藏
页码：429 / 439
页数：11
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