The genesis and evolution of homeobox gene clusters

被引：352
作者：
Garcia-Fernàndez, J [1 ]
机构：
[1] Univ Barcelona, Fac Biol, Dept Genet, E-08028 Barcelona, Spain
来源：
NATURE REVIEWS GENETICS | 2005年 / 6卷 / 12期
关键词：
D O I：
10.1038/nrg1723
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Once called the 'Rosetta stone' of developmental biology, the homeobox continues to fascinate both evolutionary and developmental biologists. The birth of the homeotic, or Hox, gene cluster, and its subsequent evolution, has been crucial in mediating the major transitions in metazoan body plan. Comparative genomics studies indicate that the more recently discovered ParaHox and NK clusters were linked to the Hox cluster early in evolution, and that together they constituted a 'megacluster' of homeobox genes that conspicuously contributed to body-plan evolution.
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页码：881 / 892
页数：12
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