A novel t(3;8)(p13;q21.1) translocation in a case of lipoblastoma

被引：9

作者：

Brinkman, Adam S. ^{[1
]}

Maxfield, Bradley ^{[2
]}

Gill, Kara ^{[2
]}

Patel, Neha J. ^{[3
]}

Gosain, Ankush ^{[1
]}

机构：

[1] Univ Wisconsin, Pediat Surg Sect, Dept Surg, Clin Sci Ctr K4 752, Madison, WI 53792 USA

[2] Univ Wisconsin, Dept Pediat Radiol, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Pediat Hematol & Oncol, Madison, WI 53706 USA

来源：

PEDIATRIC SURGERY INTERNATIONAL | 2012年 / 28卷 / 07期

关键词：

Lipoblastoma; Translocation; Chromosome; 8; PLAG1; t(3; 8)(p13; q21.1); REARRANGEMENT; CHROMOSOME-8; TUMORS;

D O I：

10.1007/s00383-012-3081-y

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Lipoblastoma is a rare benign neoplasm of embryonic white fatty tissue primarily found in the extremities of children < 3 years old (Batanian et al., Cancer Genet Cytogenet 125(1):10-13, 2001; McVay MR et al., J Pediatr Surg 41(6):1067-1071, 2006; Kamal et al., J Pediatr Surg 46(7):E9-E12, 2011). Translocations affecting the 8q11-13 region are commonly reported with lipoblastoma and proper diagnosis requires cytogenetic analysis to distinguish it from malignant myxoid liposarcoma (Miller et al., J Pediatr Surg 32(12):1771-1772, 1997; Morerio et al., Pediatr Blood Cancer 52(1):132-134, 2009). We describe an additional case of lipoblastoma containing a new translocation t(3;8)(p13;q21.1), which has not previously been reported in a healthy asymptomatic child.

引用

页码：737 / 740

页数：4

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