Lipid body function in eicosanoid synthesis: An update

被引:147
作者
Bozza, Patricia T. [1 ]
Bakker-Abreu, Ilka [2 ]
Navarro-Xavier, Roberta A.
Bandeira-Melo, Christianne [2 ]
机构
[1] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Imunofarmacol, FIOCRUZ, BR-21045900 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Lab Inflammat, Rio De Janeiro, Brazil
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2011年 / 85卷 / 05期
关键词
PLATELET-ACTIVATING-FACTOR; ENDOPEROXIDE SYNTHASE CYCLOOXYGENASE; LEUKOTRIENE C-4 SYNTHESIS; DIFFERENTIATION-RELATED PROTEIN; PROSTAGLANDIN E-2 PRODUCTION; UNSATURATED FATTY-ACIDS; LOW-DENSITY-LIPOPROTEIN; HEPATIC STELLATE CELLS; HUMAN FETAL MEMBRANES; IN-VIVO;
D O I
10.1016/j.plefa.2011.04.020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Eicosanoids (prostaglandins, leukotrienes and lipoxins) are signaling lipids derived from arachidonic acid metabolism that have important roles in physiological and pathological processes. Lately, intracellular compartmentalization of eicosanoid-synthetic machinery has emerged as a key component in the regulation of eicosanoid synthesis and functions. Over the past years substantial progresses have been made demonstrating that precursors and enzymes involved in eicosanoid synthesis localize at lipid bodies (also known as lipid droplets) and lipid bodies are distinct sites for eicosanoid generation. Here we will review the current knowledge on the functions of lipid bodies as specialized intracellular sites of compartmentalization of signaling with major roles in eicosanoid formation within cells engaged in inflammatory, infectious and neoplastic process. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:205 / 213
页数:9
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