Iodine-mediated regioselective guanylation-amination of propargylamines towards the synthesis of diversely substituted 2-aminoimidazoles

被引：15

作者：

Fedoseev, Pavel ^{[1
]}

Sharma, Nandini ^{[1
]}

Khunt, Rupesh ^{[1
]}

Ermolat'ev, Denis S. ^{[1
]}

Van der Eycken, Erik V. ^{[1
]}

机构：

[1] Univ Leuven, KU Leuven, Lab Organ & Microwave Assisted Chem, Dept Chem, Celestijnenlaan 200F, B-3001 Leuven, Belgium

来源：

RSC ADVANCES | 2016年 / 6卷 / 79期

关键词：

MICROWAVE-ASSISTED SYNTHESIS; BIOFILM FORMATION; CONCISE; CYCLIZATION; ALKALOIDS; ALKYNE; ACCESS; HYDROAMINATION; DERIVATIVES; INHIBITORS;

D O I：

10.1039/c6ra13371a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A diversity-oriented approach for the synthesis of 2-aminoimidazoles is presented. The method involves the cyclization of secondary propargylamines using iodine allowing the generation of diversely-substituted 2-aminoimidazoles. The iodo group generated during cyclization can be used for further modification, which is an additional asset of this method.

引用

页码：75202 / 75206

页数：5

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