The Implication of Autophagy in Gastric Cancer Progression

被引：16

作者：

Koustas, Evangelos ^{[1
]}

Trifylli, Eleni-Myrto ^{[1
]}

Sarantis, Panagiotis ^{[1
]}

Kontolatis, Nikolaos I. ^{[1
]}

Damaskos, Christos ^{[2
,3
]}

Garmpis, Nikolaos ^{[3
,4
]}

Vallilas, Christos ^{[1
]}

Garmpi, Anna ^{[5
]}

Papavassiliou, Athanasios G. ^{[1
]}

Karamouzis, Michalis V. ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Mol Oncol Unit, Athens 11527, Greece

[2] Laikon Gen Hosp, Renal Transplantat Unit, Athens 11527, Greece

[3] Natl & Kapodistrian Univ Athens, Med Sch, NS Christeas Lab Expt Surg & Surg Res, Athens 11527, Greece

[4] Natl & Kapodistrian Univ Athens, Med Sch, Laiko Gen Hosp, Dept Propedeut Surg 2, Athens 11527, Greece

[5] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pathol 1, Athens 11527, Greece

来源：

LIFE-BASEL | 2021年 / 11卷 / 12期

关键词：

autophagy; autophagy inducers; autophagy inhibitors; autophagy regulation; chemotherapy; gastric cancer; PROGNOSTIC-SIGNIFICANCE; VACUOLATING CYTOTOXIN; DISTAL GASTRECTOMY; RISK-FACTORS; EXPRESSION; GENE; HYDROXYCHLOROQUINE; EPIDEMIOLOGY; POPULATION; INHIBITION;

D O I：

10.3390/life11121304

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. The three entirely variable entities have distinct epidemiology, molecular characteristics, prognosis, and strategies for clinical management. However, many gastric tumors appear to be resistant to current chemotherapeutic agents. Moreover, a significant number of gastric cancer patients, with a lack of optimal treatment strategies, have reduced survival. In recent years, multiple research data have highlighted the importance of autophagy, an essential catabolic process of cytoplasmic component digestion, in cancer. The role of autophagy as a tumor suppressor or tumor promoter mechanism remains controversial. The multistep nature of the autophagy process offers a wide array of targetable points for designing novel chemotherapeutic strategies. The purpose of this review is to summarize the current knowledge regarding the interplay between gastric cancer development and the autophagy process and decipher the role of autophagy in this kind of cancer. A plethora of different agents that direct or indirect target autophagy may be a novel therapeutic approach for gastric cancer patients.

引用

页数：16

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