Differential pulse stripping voltammetric determination of the antipsychotic medication olanzapine at a magnetic nano-composite with a core/shell structure

In this work, an electrochemical sensor based on Fe3O4@Ag core/shell magnetic nanoparticles (MNPs) was used to investigate the electrochemical behaviour of olanzapine. The synthesised Fe3O4@Ag core/shell MNPs were characterised by X-ray powder diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Fe3O4@Ag core/shell MNPs were used for modification of carbon paste electrode (CPE) and the nano-composite modified electrode (Fe3O4@Ag vertical bar CPE) was utilised for electrochemical investigation of olanzapine. Fe3O4@Ag vertical bar CPE led to an enhancement in electron transfer rate (Delta E-p = 141 mV) and showed good electrocatalytic activity for oxidation of olanzapine. Fe3O4@Ag core/shell MNPs also led to a 5.4-fold enlarged effective electrode surface area. The proposed electrode showed good linearity between the anodic peak current and the concentration of olanzapine at two concentration ranges of 0.39-1.38 and 1.38-38.4 mmol L-1 and the detection limit was calculated to be 0.0018 mmol L-1. The modified electrode was used for determination of olanzapine in blood serum and plasma of schizophrenia patient.