Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis

被引：9

作者：

Landegren, Nils ^{[1
,2
]}

Lindberg, Mina Pourmousa ^{[3
]}

Skov, Jakob ^{[1
,2
]}

Hallgren, Asa ^{[1
,2
]}

Eriksson, Daniel ^{[1
,2
]}

Toft-Bertelsen, Trine Lisberg ^{[6
]}

MacAulay, Nanna ^{[6
]}

Hagforsen, Eva ^{[3
]}

Raisanen-Sokolowski, Anne ^{[7
,8
]}

Saha, Heikki ^{[9
]}

Nilsson, Thomas ^{[3
]}

Nordmark, Gunnel ^{[3
]}

Ohlsson, Sophie ^{[10
]}

Gustafsson, Jan ^{[4
]}

Husebye, Eystein S. ^{[1
,11
,12
]}

Larsson, Erik ^{[5
]}

Anderson, Mark S. ^{[13
]}

Perheentupa, Jaakko ^{[14
]}

Rorsman, Fredrik ^{[3
]}

Fenton, Robert A. ^{[15
]}

Kampe, Olle ^{[1
,2
]}

机构：

[1] Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, SE-17176 Stockholm, Sweden

[2] Uppsala Unvers, Sci Life Lab, Dept Med Sci, Uppsala, Sweden

[3] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[4] Uppsala Univ, Womens & Childrens Hlth, Uppsala, Sweden

[5] Uppsala Univ, Immunol Genet & Pathol, Uppsala, Sweden

[6] Univ Copenhagen, Dept Cellular & Mol Med, Copenhagen, Denmark

[7] Helsinki Univ Hosp, Dept Pathol, Helsinki, Finland

[8] Univ Helsinki, Helsinki, Finland

[9] Tampere Univ Hosp, Sch Med, Dept Med, Tampere, Finland

[10] Lund Univ, Dept Nephrol, Lund, Sweden

[11] Univ Bergen, Dept Clin Sci, Bergen, Norway

[12] Haukeland Hosp, Dept Med, Bergen, Norway

[13] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[14] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland

[15] Aarhus Univ, Dept Biomed, Interact Prot Epithelial Transport Ctr, Aarhus, Denmark

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2016年 / 27卷 / 10期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

CANDIDIASIS-ECTODERMAL DYSTROPHY; EXPRESSION; DISEASE; CELLS; PHOSPHORYLATION; IDENTIFICATION; AQUAPORIN-2; INVOLVEMENT; MECHANISMS; PROTEIN;

D O I：

10.1681/ASN.2015101126

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Tubulointerstitial nephritis is a common cause of kidney failure and may have diverse etiologies. This form of nephritis is sometimes associated with autoimmune disease, but the role of autoimmune mechanisms in disease development is not well understood. Here, we present the cases of three patients with autoimmune polyendocrine syndrome type 1 who developed tubulointerstitial nephritis and ESRD in association with autoantibodies against kidney collecting duct cells. One of the patients developed autoantibodies targeting the collecting duct specific water channel aquaporin 2, whereas autoantibodies of the two other patients reacted against the HOXB7 or NFAT5 transcription factors, which regulate the aquaporin 2 promoter. Our findings suggest that tubulointerstitial nephritis developed in these patients as a result of an autoimmune insult on the kidney collecting duct cells.

引用

页码：3220 / 3228

页数：9

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