Aromatic oligoamides with increased backbone flexibility: improved synthetic efficiencies, solvent-dependent folding and cooperative conformational transitions

被引：4

作者：

Liu, Rui ^{[1
,2
]}

Connor, Alan L. ^{[1
]}

Al-mkhaizim, Fayez Y. ^{[1
]}

Gong, Bing ^{[1
,2
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

[2] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2015年 / 39卷 / 05期

基金：

美国国家科学基金会;

关键词：

HYDROGEN-BONDING INTERACTIONS; HELICAL SECONDARY STRUCTURE; SELF-ORGANIZATION; BETA-PEPTIDES; AMINO-ACID; FOLDAMERS; OLIGOMERS; FAMILY; POLYPEPTOIDS; AGGREGATION;

D O I：

10.1039/c4nj01820f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aromatic oligoamides 2a, 2b, and 2c of increasing chain lengths were prepared and further characterized for their folding behaviour. These oligomers were derived by relaxing the backbone-constraint of a series of oligoamides that fold into well-defined conformations. With their backbones of increased flexibility, the resultant 2a-c were found to form with considerably improved efficiencies, and undergo highly cooperative folding that depends on chain length, solvents, and temperature.

引用

页码：3217 / 3220

页数：4