Hypothalamus volume in twin pairs discordant for schizophrenia

被引：38

作者：

M. P. Koolschijn, P. Cedric ^{[1
]}

M. van Haren, Neeltje E. ^{[1
]}

Hulshoff Pol, Hilleke E. ^{[1
]}

Kahn, Rene S. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3584 CX Utrecht, Netherlands

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2008年 / 18卷 / 04期

关键词：

schizophrenia; twins; hypothalamus; discordant; genetic risk; magnetic resonance imaging;

D O I：

10.1016/j.euroneuro.2007.12.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Monozygotic and same-sex dizygotic twin pairs discordant for schizophrenia were compared with matched control twin pairs in order to disentangle genetic and environmental contributions to variation in hypothalamus volume. A decrease in hypothalamus volume was found in patients or discordant twin pairs compared to healthy controls which could be attributed to the decrease in total brain volume. Higher within-twin pair similarities in monozygotic compared to dizygotic twin pairs, suggests that hypothalamus volume might be partly genetically controlled. (c) 2007 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：312 / 315

页数：4

共 26 条

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