Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness

被引：17

作者：

Luykx, Jurjen J. ^{[1
,2
,3
]}

Loef, Dore ^{[4
,7
]}

Lin, Bochao ^{[1
,2
,8
]}

van Diermen, Linda ^{[13
,14
,15
,16
]}

Nuninga, Jasper O. ^{[10
]}

van Exel, Eric ^{[4
,7
]}

Oudega, Mardien L. ^{[4
,7
]}

Rhebergen, Didi ^{[4
,7
,11
]}

Schouws, Sigfried N. T. M. ^{[4
,7
]}

van Eijndhoven, Philip ^{[9
]}

Verwijk, Esmee ^{[5
,6
]}

Schrijvers, Didier ^{[13
,14
,15
]}

Birkenhager, Tom K. ^{[12
,14
,15
]}

Ryan, Karen M. ^{[17
,18
]}

Arts, Baer ^{[2
]}

van Bronswijk, Suzanne C. ^{[2
]}

Kenis, Gunter ^{[2
]}

Schurgers, Geert ^{[2
,22
]}

Baune, Bernhard T. ^{[19
,20
,21
]}

Arns, Martijn ^{[8
]}

van Dellen, Edwin E. ^{[1
]}

Somers, Metten ^{[1
]}

Sommer, Iris E. C. ^{[10
]}

Boks, Marco P. ^{[1
]}

Guloksuz, Sinan ^{[2
]}

McLoughlin, Declan M. ^{[1
]}

Dols, Annemiek ^{[4
,7
]}

Rutten, Bart P. F. ^{[2
]}

机构：

[1] Univ Utrecht, Dept Psychiat, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Utrecht, Netherlands

[2] Maastricht Univ, Med Ctr, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[3] GGNet Mental Hlth, Outpatient Opin Clin 2, Warnsveld, Netherlands

[4] Amsterdam UMC, Dept Psychiat, Amsterdam Neurosci, Locat VUmc, Amsterdam, Netherlands

[5] Univ Amsterdam, Dept Psychol, Amsterdam, Netherlands

[6] Univ Amsterdam, Med Ctr, Dept Med Psychol, Amsterdam, Netherlands

[7] GGZ InGeest Specialized Mental Hlth Care, Amsterdam, Netherlands

[8] Brainclin Fdn, Res Inst Brainclin, Nijmegen, Netherlands

[9] Radboud UMC, Dept Psychiat, Nijmegen, Netherlands

[10] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci Cells & Syst, Groningen, Netherlands

[11] Mental Hlth Care Inst GGZ Cent, Amersfoort, Netherlands

[12] Erasmus Univ, Med Ctr, Dept Psychiat, Rotterdam, Netherlands

[13] Univ Psychiat Ctr Duffel, Duffel, Netherlands

[14] Univ Antwerp, Dept Psychiat, Antwerp, Belgium

[15] Univ Antwerp, Collaborat Antwerp Psychiat Res Inst, Fac Med & Hlth Sci, Antwerp, Belgium

[16] Psychiat Ctr Bethanie, Zoersel, Belgium

[17] St Patricks Univ Hosp, Dept Psychiat, Dublin, Ireland

[18] St Patricks Univ Hosp, Trinity Coll, Inst Neurosci, Dublin, Ireland

[19] Univ Munster, Dept Psychiat, Munster, Germany

[20] Melbourne Med Sch, Dept Psychiat, Melbourne, Vic, Australia

[21] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[22] Yale Univ, Sch Med, SG Dept Psychiat, New Haven, CT USA

来源：

BIOLOGICAL PSYCHIATRY | 2022年 / 91卷 / 06期

基金：

荷兰研究理事会;

关键词：

MAJOR DEPRESSION; RATING-SCALE; POPULATION;

D O I：

10.1016/j.biopsych.2021.10.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BACKGROUND: Electroconvulsive therapy (ECT) is the most effective treatment for severe major depressive episodes (MDEs). Nonetheless, firmly established associations between ECT outcomes and biological variables are currently lacking. Polygenic risk scores (PRSs) carry clinical potential, but associations with treatment response in psychiatry are seldom reported. Here, we examined whether PRSs for major depressive disorder, schizophrenia (SCZ), cross-disorder, and pharmacological antidepressant response are associated with ECT effectiveness. METHODS: A total of 288 patients with MDE from 3 countries were included. The main outcome was a change in the 17-item Hamilton Depression Rating Scale scores from before to after ECT treatment. Secondary outcomes were response and remission. Regression analyses with PRSs as independent variables and several covariates were performed. Explained variance (R2) at the optimal p-value threshold is reported. RESULTS: In the 266 subjects passing quality control, the PRS-SCZ was positively associated with a larger Hamilton Depression Rating Scale decrease in linear regression (optimal p-value threshold = .05, R2 = 6.94%, p < .0001), which was consistent across countries: Ireland (R2 = 8.18%, p = .0013), Belgium (R2 = 6.83%, p = .016), and the Netherlands (R2 = 7.92%, p = .0077). The PRS-SCZ was also positively associated with remission (R2 = 4.63%, p = .0018). Sensitivity and subgroup analyses, including in MDE without psychotic features (R2 = 4.42%, p = .0024) and unipolar MDE only (R2 = 9.08%, p < .0001), confirmed the results. The other PRSs were not associated with a change in the Hamilton Depression Rating Scale score at the predefined Bonferroni-corrected significance threshold. CONCLUSIONS: A linear association between PRS-SCZ and ECT outcome was uncovered. Although it is too early to adopt PRSs in ECT clinical decision making, these findings strengthen the positioning of PRS-SCZ as relevant to treatment response in psychiatry.

引用

页码：531 / 539

页数：9

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