Bridging the regeneration gap: Stem cells, biomaterials and clinical translation in bone tissue engineering

被引：115
作者：
Dawson, Jonathan I. [1 ]
Oreffo, Richard O. C. [1 ]
机构：
[1] Univ Southampton, Bone & Joint Res Grp, Ctr Human Dev Stem Cell & Regenerat Dev Origins H, Inst Dev Sci, Southampton SO16 6YD, Hants, England
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2008年 / 473卷 / 02期
基金：
英国生物技术与生命科学研究理事会;
关键词：
skeletal stem cell; tissue regeneration; osteoprogenitor; ex vivo expansion; bone tissue engineering; biomimetic scaffolds;
D O I：
10.1016/j.abb.2008.03.024
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Advances in our understanding of skeletal stem cells and their role in bone development and repair, offer the potential to open new frontiers in bone regeneration. Tissue engineering seeks to harness the regenerative capacity innate to bone for the replacement of tissue lost or damaged through a broad range of conditions associated with an increasingly aged population. The strategy entails ex vivo expansion of multipotential populations followed by delivery to the site of damage on dynamically durable-biodegradable three-dimensional structures which Provide the requisite extracellular microenvironment for stem cell driven tissue development. This review will examine bone stem cell biology, and current advances in skeletal tissue engineering through the enhancement and marrying of biologically informed and clinically relevant strategies. (C) 2008 Elsevier Inc. All rights reserved.
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收藏
页码：124 / 131
页数：8
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