Anti-hyperglycemic and liver protective effects of flavonoids from Psidium guajava']java L. (guava) leaf in diabetic mice

被引：50

作者：

Zhu, Xiaoai ^{[1
,2
,3
]}

Ouyang, Wen ^{[4
]}

Lan, Yaqi ^{[2
]}

Xiao, Hang ^{[3
]}

Tang, Lan ^{[5
]}

Liu, Guo ^{[2
]}

Feng, Konglong ^{[2
]}

Zhang, Liqun ^{[6
]}

Song, Mingyue ^{[2
]}

Cao, Yong ^{[2
]}

机构：

[1] Henan Univ Technol, Sch Food Sci & Technol, Zhengzhou 450001, Henan, Peoples R China

[2] South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Nutraceut & Funct Foods, Guangzhou 510642, Guangdong, Peoples R China

[3] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

[4] Hunan Univ Chinese Med, Sch Pharm, Changsha 410007, Hunan, Peoples R China

[5] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China

[6] Guangzhou Univ Chinese Med, Coll Basic Med Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

FOOD BIOSCIENCE | 2020年 / 35卷

基金：

中国国家自然科学基金;

关键词：

Psidium gua[!text type='java']java[!/text] L. leaf; Flavonoids; Anti-hyperglycemic; Liver protection; HIGH-FAT DIET; GLUCOSE-UPTAKE; EXTRACT; STREPTOZOTOCIN; POLYSACCHARIDES; ACCUMULATION; ANTIOXIDANT; GLYCOSIDES; MODEL;

D O I：

10.1016/j.fbio.2020.100574

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Guava leaf flavonoids were obtained using a simple extraction method to evaluate their anti-hyperglycemic and liver protective effects with a high-fat diet and a low-dose streptozotocin induced diabetic mouse model. Flavonoids supplementation significantly decreased fasting plasma glucose, glucose tolerance, and the insulin resistance index in diabetic mice, lowered the serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol compared to the diabetic control group (p < 0.05). Furthermore, guava leaf flavonoids significantly decreased the liver and kidney indexes, and improved hepatocyte morphology in diabetic mice. Taken together, these results showed that guava leaf flavonoids had significant anti-diabetic and liver protective activities in diabetic mice. This study could facilitate the development of hypoglycemic functional foods from guava leaves.

引用

页数：8

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