Recombinant Chicken Interferon-α Inhibits H9N2 Avian Influenza Virus Replication In Vivo by Oral Administration

被引：53
作者：
Meng, Shanshan [1 ,2 ]
Yang, Limin [1 ]
Xu, Chongfeng [1 ,2 ]
Qin, Zhuoming [3 ]
Xu, Huaiying [3 ]
Wang, Youling [3 ]
Sun, Lei [1 ]
Liu, Wenjun [1 ,4 ]
机构：
[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
[3] Shandong Acad Agr Sci, Inst Poultry Sci, Jinan, Peoples R China
[4] Chinese Acad Sci, Inst Microbiol, China Japan Joint Lab Mol Immunol & Mol Microbiol, Beijing 100101, Peoples R China
来源：
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2011年 / 31卷 / 07期
关键词：
BURSAL DISEASE VIRUS; A VIRUSES; SOUTHEASTERN CHINA; ANTIVIRAL ACTIVITY; NEWCASTLE-DISEASE; GENE-EXPRESSION; INFECTION; EVOLUTION; PATHOGENICITY; PROFILES;
D O I：
10.1089/jir.2010.0123
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chicken interferon-alpha (ChIFN-alpha) has been demonstrated to be an important cytokine in antiviral immunity. However, the preventive or therapeutic effect of ChIFN-alpha as an oral antiviral agent on avian influenza virus (AIV) infection has not been fully clarified in chickens systemically. In the present study, we investigated the anti-H9N2 AIV effect of ChIFN-alpha on a cohort of 7- and 33-day-old specific pathogen-free (SPF) chickens by oral administration. Results showed that both the ChIFN-alpha preventive and therapeutic groups exhibited significantly reduced viral load in trachea when compared with the virus-challenged control group. The therapeutic effect was better than the preventive effect on 7-day-old SPF chickens, which is opposite to 33-day-old SPF chickens. We speculated that T-dependent lymphocyte system of 33-day-old SPF chickens might be easier to be stimulated by ChIFN-alpha than that of 7-day-old SPF chickens. In addition, there was no side effect on the body weight of chickens treated with ChIFN-alpha. We also found that IFN-stimulated genes (ISGs) (2',5'-oligoadenylate synthetase and Mx1) were upregulated in groups treated by ChIFN-alpha and/or virus, indicating that these 2 ISGs not only participated in anti-AIV response in vivo but also could be induced by oral administration of ChIFN-alpha. The present study suggested that ChIFN-alpha could be used as a potential preventive and therapeutic antiviral agent against H9N2 AIV infection by oral administration.
引用
收藏
页码：533 / 538
页数：6
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