Determination of Posaconazole Levels in Toenails of Adults with Onychomycosis following Oral Treatment with Four Regimens of Posaconazole for 12 or 24 Weeks

被引：8

作者：

Krishna, Gopal ^{[1
]}

Ma, Lei ^{[1
]}

Martinho, Monika ^{[1
]}

Prasad, Pratapa ^{[1
]}

Wahl, Janice ^{[1
]}

Tavakkol, Amir ^{[1
]}

机构：

[1] Merck Sharp & Dohme Corp, Whitehouse Stn, NJ USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 09期

关键词：

ITRACONAZOLE; NAIL; PHARMACOKINETICS; TERBINAFINE;

D O I：

10.1128/AAC.01302-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pharmacokinetic data from a randomized, parallel-group, multicenter study are presented. Adults with toenail onychomycosis (n = 146) received posaconazole (100 mg, 200 mg, or 400 mg) once daily (QD) for 24 weeks or 400 mg QD for 12 weeks. The posaconazole concentration in the great toenail exhibited a dose-related increase starting at week 2 for 24 weeks and a mean toenail-to-plasma concentration ratio of approximately 3:1 at the end of treatment for the 400-mg 24-week dose.

引用

收藏

页码：4424 / 4426

页数：3

相关论文

共 7 条

[1] Pharmacokinetics of antifungal agents in onychomycoses [J].

Debruyne, D ;

Coquerel, A .

CLINICAL PHARMACOKINETICS, 2001, 40 (06) :441-472

[2]

DYKES PJ, 1990, BRIT J DERMATOL, V123, P481, DOI 10.1111/j.1365-2133.1990.tb01453.x

[3] In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species [J].

Gupta, AK ;

Kohli, Y ;

Batra, R .

MEDICAL MYCOLOGY, 2005, 43 (02) :179-185

[4] Skin Concentrations and Pharmacokinetics of Posaconazole after Oral Administration [J].

Krishna, Gopal ;

Beresford, Eric ;

Ma, Lei ;

Vickery, Donna ;

Martinho, Monika ;

Yu, Xin ;

Komjathy, Steven ;

Tavakkol, Amir .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) :1807-1810

[5] ITRACONAZOLE PENETRATES THE NAIL VIA THE NAIL MATRIX AND THE NAIL BED - AN INVESTIGATION IN ONYCHOMYCOSIS [J].

MATTHIEU, L ;

DEDONCKER, P ;

CAUWENBERGH, G ;

WOESTENBORGHS, R ;

VANDEVELDE, V ;

JANSSEN, PAJ ;

DOCKX, P .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1991, 16 (05) :374-376

[6] A sensitive liquid chromatography and mass spectrometry method for the determination of posaconazole in human plasma [J].

Shen, Jim X. ;

Krishna, Gopal ;

Hayes, Roger N. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 43 (01) :228-236

[7] POSTTREATMENT ITRACONAZOLE LEVELS IN THE NAIL [J].

WILLEMSEN, M ;

DEDONCKER, P ;

WILLEMS, J ;

WOESTENBORGHS, R ;

VANDEVELDE, V ;

HEYKANTS, J ;

VANCUTSEM, J ;

CAUWENBERGH, G ;

ROSEEUW, D .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1992, 26 (05) :731-735