Visible-light-mediated direct perfluoroalkylation and trifluoromethylation of free anilines

被引：20
作者：
He, Chun-Yang [1 ]
Gu, Ji-Wei [2 ]
Zhang, Xingang [2 ]
机构：
[1] Zunyi Med Univ, Sch Pharm, 6 West Xuefu Rd, Zunyi 563003, Guizhou, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 41期
基金：
中国国家自然科学基金;
关键词：
Perfluoroalkylation; Trifluoromethylation; Anilines; Photoredox catalysis; Visible-light; MEDICINAL CHEMISTRY; PHOTOREDOX CATALYSIS; FLUORINE; ALKENES; ARENES; FLUOROALKYLATION; HETEROARENES; AROMATICS;
D O I：
10.1016/j.tetlet.2017.09.010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild, operationally simple method for direct perfluoroalkylation and trifluoromethylation of anilines through visible-light-mediated photoredox catalysis from broadly available perfluoroalkyl iodides and free anilines is described. The method provides a facile route for application in drug discovery and development. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3939 / 3941
页数：3
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