Cu(II) ionic liquid promoted Simple and Economical Synthesis of 1,4-disubstituted-1,2,3-triazoles with Low Catalyst Loading

被引：7

作者：

Phukan, Parmita ^{[1
]}

Kulshrestha, Akshay ^{[2
]}

Kumar, Arvind ^{[2
]}

Chakraborti, Srijita ^{[3
]}

Chattopadhyay, Pronobesh ^{[3
]}

Sarma, Diganta ^{[1
]}

机构：

[1] Dibrugarh Univ, Dept Chem, Dibrugarh, Assam, India

[2] Council Sci & Ind Res CSIR, Cent Salt & Marine Chem Res Inst, Acad Sci & Innovat Res AcSIR, Bhavnagar, Gujarat, India

[3] Def Res Lab, Tezpur, Assam, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2021年 / 133卷 / 04期

关键词：

Green chemistry; ionic liquid; CuAAC; non-toxic; low metal loading; ALKYNE CYCLOADDITION REACTIONS; ASYMMETRIC HYDROGENATION; REGIOSELECTIVE SYNTHESIS; AEROBIC OXIDATION; GREEN ROUTE; COMPLEXES; COPPER; 1,2,3-TRIAZOLES; EFFICIENT; CHLORIDE;

D O I：

10.1007/s12039-021-01980-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we have described a very simple and low metal loading copper-based ionic liquid as solvent and catalyst for regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles. The proposed protocol proved its efficiency by showing excellent tolerance to a large array of electronically diverse substrates without the use of the external base, solvent and ligands. Moreover, from cytotoxicity analysis the catalyst was found to be non-toxic in nature due to extremely low loading of copper metal (0.1 mol %).

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页数：8

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