Proline-mediated enantioselective construction of tetrahydropyridines via a cascade Mannich-Type/Intramolecular Cyclization reaction

被引：60

作者：

Han, Rong-Gang ^{[1
]}

Wang, Yao ^{[1
]}

Li, Yu-Ye ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 10期

关键词：

cascade reactions; imines; Mannich-type; reaction; organocatalysis; tetrahydropyridines;

D O I：

10.1002/adsc.200800253

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A highly diastereo- and enantioselective synthesis of 2,3-disubstituted tetrahydropyridines was accomplished via a proline-mediated cascade Mannich-type/intramolecular cyclization reaction from preformed N-PMP (p-methoxyphenyl) aldimines and inexpensive aqueous tetrahydro-2Hpyran-2,6-diol.

引用

页码：1474 / 1478

页数：5

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