Use of human tissue in ADME and safety profiling of development candidates

被引：6

作者：

Coleman, RA ^{[1
]}

Bowen, WP ^{[1
]}

Baines, IA ^{[1
]}

Woodrooffe, AJ ^{[1
]}

Brown, AM ^{[1
]}

机构：

[1] Pharmagene Labs, Royston SG8 5HD, Herts, England

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 21期

关键词：

D O I：

10.1016/S1359-6446(01)01977-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The clinical success of a compound is often curtailed because of inadequate safety, pharmacokinetics or efficacy. Human tissue can be used to identify the potential shortcomings of new drugs before they undergo testing in man. This review highlights the consent and ethical approval required for the use of human tissues and discusses their use for predicting human ADME and safety profiles of drugs in preclinical development. The ability to retrieve a wide range of viable tissues from human donors provides the opportunity to test drugs for many potential use-limiting side-effects.

引用

页码：1116 / 1126

页数：11

共 57 条

[1] METHODS OF INVESTIGATING INTESTINAL TRANSPORT [J].