Initial survival data of kidney transplant patients with pre-transplant monoclonal gammopathy

被引:14
作者
Soltero, Liliana [1 ,2 ,3 ]
Carbajal, Hector [1 ,2 ,4 ]
Xu, Jiaqiong [5 ]
McCarthy, John [2 ,4 ]
Suki, Wadi N. [1 ,2 ,3 ,6 ]
Gaber, A. Osama [1 ,2 ]
Adrogue, Horacio E. [1 ,2 ,4 ]
机构
[1] Methodist Hosp, Dept Surg, Methodist JC Walter Jr Transplant Ctr, Houston, TX 77030 USA
[2] Weill Cornell Med Coll, New York, NY USA
[3] Methodist Hosp, Kidney Inst, Houston, TX 77030 USA
[4] Methodist Hosp, Dept Med, Houston, TX 77030 USA
[5] Methodist Hosp, Ctr Biostat, Res Inst, Houston, TX 77030 USA
[6] Baylor Coll Med, Dept Med, Div Renal, Houston, TX 77030 USA
关键词
gammopathy; malignancy; MGUS; survival; TERM-FOLLOW-UP; UNDETERMINED SIGNIFICANCE; IMMUNOGLOBULIN ABNORMALITIES; RENAL-TRANSPLANTATION; MULTIPLE-MYELOMA; RISK-FACTORS; RECIPIENTS; PROGRESSION; MORTALITY; SERUM;
D O I
10.1111/j.1399-0012.2011.01539.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: Monoclonal gammopathy of undetermined significance (MGUS) is the presence of a serum monoclonal protein at a concentration of <3 g/dL without evidence of lymphoproliferative disease or organ damage. The prevalence of MGUS in kidney transplantation (KT) candidates is unknown. The present is a retrospective report of patients who underwent evaluation for a KT and were found to have MGUS at our center. Methods: All transplant candidates found to have MGUS between the years 2000 and 2007 were included. Variables were collected. Patients with MGUS that received a KT were compared with patients with MGUS that were not transplanted. Results: Of a total of 1215 KT candidates, 34 were found to have MGUS during the KT evaluation. Nine patients with MGUS were transplanted. Myeloma or lymphoproliferative disease was not observed. Following transplantation, the MGUS group had a lower survival than the non-transplanted group. However, survival from the time of MGUS diagnosis was not different between the transplanted and non-transplanted MGUS groups. Conclusions: In this group, transplantation did not confer a survival benefit. It is our hope that these initial data will serve as a platform for future studies. We suggest MGUS screening in all patients older than 50 yr of age undergoing evaluation for transplantation.
引用
收藏
页码:300 / 304
页数:5
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