General partially linear varying-coefficient transformation model with right censored data

In this paper, a unified maximum marginal likelihood estimation procedure is proposed for the analysis of right censored data using general partially linear varying-coefficient transformation models (GPLVCTM), which are flexible enough to include many survival models as its special cases. Unknown functional coefficients in the models are approximated by cubic B-spline polynomial. We estimate B-spline coefficients and regression parameters by maximizing marginal likelihood function. One advantage of this procedure is that it is free of both baseline and censoring distribution. Through simulation studies and a real data application (VA data from the Veteran's Administration Lung Cancer Study Clinical Trial), we illustrate that the proposed estimation procedure is accurate, stable and practical. (C) 2011 Elsevier B.V. All rights reserved.