EXPEDIENT N-ARYLATION FOR THE SYNTHESIS OF 2-ARYLAMINO-3-CYANOPYRIDINES USING IONIC COPPER(I) COMPLEX AS A CATALYST

被引：2

作者：

Zhang, Min ^{[1
]}

Xiong, Biao ^{[1
]}

Wang, Ting ^{[1
]}

Wang, Xiaoting ^{[1
]}

Van, Fengxia ^{[1
]}

Ding, Yuqiang ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Food Colloids & Biotechnol, Minist Educ, Wuxi 214122, Peoples R China

来源：

HETEROCYCLES | 2012年 / 85卷 / 06期

基金：

中国国家自然科学基金;

关键词：

N-Arylation; 2-Arylamio-3-cyanopyridine; Aryl Halide; Copper Catalysis; Ullmann Coupling; ONE-POT SYNTHESIS; TERMINAL ALKYNES; BOND FORMATION; MICROWAVE IRRADIATION; RUTHENIUM COMPLEXES; REUSABLE CATALYST; ARYL AMINATION; C-N; 2-AMINOPYRIDINES; EFFICIENT;

D O I：

10.3987/COM-12-12461

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-arylation of 2-amino-3-cyanopyridines is firstly described by using ionic copper(I) complex (Phen)(2)Cu+BF4- (phen = 1,10-phenanthroline) as an efficient catalyst. The synthetic protocol can be applied to synthesize a wide range of 2-arylamino-3-cyanopyridine products in good to excellent isolated yields. The resulted products are potentially building blocks for further preparation of biologically interesting products or useful ligands for metal catalysis.

引用

页码：1393 / 1404

页数：12

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