Reduced circulating miR-196b levels is associated with preeclampsia

被引：9

作者：

Campos, C. B. ^{[1
]}

Marques, T. M. ^{[2
]}

Pereira, R. W. ^{[2
]}

Sandrim, V. C. ^{[1
]}

机构：

[1] Santa Casa Belo Horizonte, Nucleo Posgrad & Pesquisa, Belo Horizonte, MG, Brazil

[2] Univ Catolica Brasilia, Programa Posgrad Ciencias Genom & Biotecnol, BR-70790160 Brasilia, DF, Brazil

来源：

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | 2014年 / 4卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Preeclampsia; Circulating microRNA; miR-196b; MICRORNAS; EXPRESSION;

D O I：

10.1016/j.preghy.2013.10.002

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

MicroRNAs (miRs) are small noncoding RNAs, highly stable in plasma, that regulate gene expression by base-pairing to the 3'-untranslated region of target mRNAs. We compared the expression of 3 circulating miRs (miR-125b, miR-146a, and miR-196b), which is related to the control of cell proliferation, differentiation, and apoptosis in preeclamptic (n = 19) and healthy pregnant women (n = 14). We found that women with preeclampsia (PE) presented lower expression of miR-196b (-2.9-fold change). The other miRs were at similar levels. This study is the first to demonstrate this difference, and highlights new opportunities for investigation into the role of miRs in PE. (C) 2013 International Society for the Study of Hypertension in Pregnancy Published by Elsevier B.V. All rights reserved.

引用

页码：11 / 13

页数：3

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