Differential Effects of Acute (Extenuating) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus

被引：36

作者：

de Lemos, Edite Teixeira ^{[1
,2
]}

Pinto, Rui ^{[3
]}

Oliveira, Jorge ^{[2
,4
]}

Garrido, Patricia ^{[1
]}

Sereno, Jose ^{[1
]}

Mascarenhas-Melo, Filipa ^{[1
]}

Pascoa-Pinheiro, Joao

Teixeira, Frederico ^{[1
]}

Reis, Flavio ^{[1
]}

机构：

[1] Univ Coimbra, Lab Pharmacol & Expt Therapeut, Inst Biomed Res Light & Image IBILI, Fac Med, P-3000548 Coimbra, Portugal

[2] Polytech Inst Viseu, Educ Technol & Hlth Study Ctr, P-3504510 Viseu, Portugal

[3] Univ Lisbon, Unit Pharmacol & Pharmacotoxicol, Fac Pharm, P-1649003 Lisbon, Portugal

[4] Polytech Inst Viseu, Agr Sch Viseu, P-3500606 Viseu, Portugal

来源：

MEDIATORS OF INFLAMMATION | 2011年 / 2011卷

关键词：

KAPPA-B ACTIVATION; SKELETAL-MUSCLE; INSULIN SENSITIVITY; XANTHINE-OXIDASE; TNF-ALPHA; ADIPONECTIN; GLUCOSE; RESISTANCE; PREVENTS; CARBOHYDRATE;

D O I：

10.1155/2011/253061

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study compares the effects of a single bout of exercise (acute extenuating) with those promoted by an exercise training program (chronic), focusing on low-grade chronic inflammation profile and on oxidative stress status, using the obese ZDF rats as a model of type 2 diabetes mellitus (T2DM). Animals were sacrificed after 12 weeks of a swimming training program and after a single bout of acute extenuating exercise. Glycaemic, insulinemic, and lipidic profile (triglycerides, total-cholesterol) were evaluated, as well as inflammatory (serum CRPhs, TNF-alpha, adiponectin) and oxidative (lipidic peroxidation and uric acid) status. When compared to obese diabetic sedentary rats, the animals submitted to acute exercise presented significantly lower values of glycaemia and insulinaemia, with inflammatory profile and oxidative stress significantly aggravated. The trained animals showed amelioration of glycaemic and lipidic dysmetabolism, accompanied by remarkable reduction of inflammatory and oxidative markers. In conclusion, the results presented herein suggessted that exercise pathogenesis-oriented interventions should not exacerbate underlying inflammatory stress associated with T2DM.

引用

页数：8

共 62 条

[1] Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPARγ2 expression in adipocytes [J].

Ajuwon, KM ;

Spurlock, ME .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2005, 288 (05) :R1220-R1225

[2] Heart, liver, and skeletal muscle myeloperoxidase activity during exercise [J].

Belcastro, AN ;

Arthur, GD ;

Albisser, TA ;

Raj, DA .

JOURNAL OF APPLIED PHYSIOLOGY, 1996, 80 (04) :1331-1335

[3] ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism [J].

Berg, AH ;

Combs, TP ;

Scherer, PE .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (02) :84-89

[4] Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity - Studies in subjects with various degrees of glucose tolerance and insulin sensitivity [J].

Bonora, E ;

Saggiani, F ;

Targher, G ;

Zenere, MB ;

Alberiche, M ;

Monauni, T ;

Bonadonna, RC ;

Muggeo, M .

DIABETES CARE, 2000, 23 (01) :57-63

[5] Exercise and insulin sensitivity: A review [J].

Borghouts, LB ;

Keizer, HA .

INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2000, 21 (01) :1-12

[6] Effects of exercise training on glucose homeostasis [J].

Boulé, NG ;

Weisnagel, SJ ;

Lakka, TA ;

Tremblay, A ;

Bergman, RN ;

Rankinen, T ;

Leon, AS ;

Skinner, JS ;

Wilmore, JH ;

Rao, DC ;

Bouchard, C .

DIABETES CARE, 2005, 28 (01) :108-114

[7] The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases [J].

Brandt, Claus ;

Pedersen, Bente K. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,

[8] Glucotoxicity and pancreatic proteomics [J].

Brunner, Yannick ;

Schvartz, Domitille ;

Priego-Capote, Feliciano ;

Coute, Yohann ;

Sanchez, Jean-Charles .

JOURNAL OF PROTEOMICS, 2009, 71 (06) :576-591

[9] Antioxidant Anti-Inflammatory Treatment in Type 2 Diabetes [J].

Ceriello, Antonio ;

Testa, Roberto .

DIABETES CARE, 2009, 32 :S232-S236

[10]

Chang YC, 2010, AM J TRANSL RES, V2, P316

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