Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status

Few studies have evaluated the relationship between the consumption of dietary folate and one-carbon metabolism-related nutrients and breast cancer risk defined by oestrogen receptor (ER) and progesterone receptor (PR) status. The objective of the present study was to examine the associations between dietary folate, vitamin B-6, vitamin B-12, and methionine intake and the risk of breast cancer by ER and PR status among Chinese women in Guangdong. A hospital-based case-control study was conducted from June 2007 to August 2008, with 438 cases and 438 age (5-year interval)- and residence (rural/urban)-matched controls. Dietary intake information was assessed using a validated FFQ administered through a face-to-face interview. Unconditional logistic regression models were used to calculate multivariate-adjusted OR and 95% CI. A significant inverse association was found between dietary folate and vitamin B-6 intake and breast cancer risk. The adjusted OR of the highest v. the lowest quartile were 0.32 (95% CI 0.21, 0.49; P-trend < 0.001) for dietary folate and 0.46 (95% CI 0.30, 0.69; P-trend < 0.001) for vitamin B-6. No associations were observed for vitamin B-12 and methionine intake. A significant inverse association between dietary folate intake and breast cancer risk was observed in all subtypes of ER and PR status. These findings suggest that dietary folate and vitamin B-6 intakes were inversely associated with breast cancer risk. The inverse association did not differ by ER and/or PR status.