Dechlorination of the dietary nona-chlorinated toxaphene congeners 62 and 50 into the octa-chlorinated toxaphene congeners 44 and 40 in zebrafish (Danio rerio) and Atlantic salmon (Salmo salar)

被引：5
作者：
Berntssen, M. H. G. [1 ]
Lundebye, A. -K. [1 ]
Hop-Johannessen, L. [1 ]
Lock, E. -J. [1 ]
机构：
[1] Natl Inst Nutr & Seafood Res NIFES, N-5817 Bergen, Norway
来源：
AQUATIC TOXICOLOGY | 2012年 / 112卷
关键词：
Toxaphene; Parlar; Atlantic salmon; Zebrafish; Biotransformation; Dechlorination; PERSISTENT ORGANIC POLLUTANTS; REDUCTIVE DECHLORINATION; TECHNICAL TOXAPHENE; FARMED SALMON; ANAEROBIC CONDITIONS; MASS-SPECTROMETRY; WILD SALMON; FISH; BIOACCUMULATION; CONTAMINANTS;
D O I：
10.1016/j.aquatox.2012.01.024
中图分类号：
Q17 [水生生物学];
学科分类号：
071004 ;
摘要：
The relative feed-to-fish accumulation and possible biotransformation of the nona-chlorinated toxaphene congeners currently included in EU-legislation (CHB-50 and -62) and the octa-chlorinated congeners recommended by the European Food Safety Authority to be included in future surveillance of fish samples (CHB-40, 41, and 44) were investigated in the present study. Model fish Danio rerio were fed either (a) diets spiked with a combination as well as the pure individual toxaphene congeners CHB-50 or 62 or (b) diets spiked with the combination of CHB Sigma 50 + 62 and/or CHB Sigma 40+41+44. In addition, seawater adapted Atlantic salmon smolts were fed technical toxaphene enriched feeds for 62 days. Zebrafish fed a diet containing CHB-50 and CHB-62 accumulated newly formed CHB-40&41 and CHB-44, respectively. The biomagnifications factors (BMF) of the toxaphene congeners in Atlantic salmon muscle from the feeds spiked with technical toxaphene were significantly correlated with their relative lipophilicity (expressed as log K-ow). An exception was CHB-44 which had a higher BMF than could be expected from its specific log K-ow, reflecting that CHB-44 is a metabolite formed under dietary exposure to CHB-62. This paper reports the in vivo dechlorination of nona-chlorinated toxaphene congeners into octa-chlorinated congeners in feeding trials with a model fish (zebrafish) and an oily food fish (Atlantic salmon). (C) 2012 Elsevier B.V. All rights reserved.
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页码：54 / 61
页数：8
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