Antitumor dinuclear platinum(II) complexes derived from a novel chiral ligand

被引：15
作者：
Gao, Chuanzhu [1 ,2 ]
Xu, Gang [1 ,2 ,3 ]
Gou, Shaohua [1 ,2 ,3 ]
机构：
[1] Southeast Univ, Pharmaceut Res Ctr, Nanjing 211189, Peoples R China
[2] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Peoples R China
[3] Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 21期
基金：
中国国家自然科学基金;
关键词：
1R; 2R-Diaminocyclohexane derivative; Dinuclear platinum(II) complexes; Cytotoxicity;
D O I：
10.1016/j.bmcl.2011.08.100
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new chiral ligand, 2-(((1R,2R)-2-aminocyclohexyl) amino) acetic acid (HL), was designed and synthesized to prepare a series of novel dinuclear platinum(II) complexes with dicarboxylates or sulfate as bridges. The evaluation of these metal complexes in vitro cytotoxicity against human HCT-116, MCF-7 and HepG-2 cell lines were made. All compounds showed antitumor activity to HCT-116 and MCF-7. Particularly, compounds M3 and M5 not only exhibited better activity than carboplatin against MCF-7 and HepG-2, but also showed very close activity to oxaliplatin against HCT-116. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6386 / 6388
页数：3
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