SENSOR SYSTEM BASED ON A PIEZOELECTRIC RESONATOR WITH A LATERAL ELECTRIC FIELD FOR VIRUS DIAGNOSTICS

被引：7
|
作者：
Guliy, Olga I. [1 ]
Zaitsev, Boris D. [2 ]
Semyonov, Alexander P. [2 ]
Karavaeva, Olga A. [1 ,2 ]
Fomin, Alexander S. [1 ]
Staroverov, Sergey A. [1 ]
Burov, Andrey M. [1 ]
Borodina, Irina A. [2 ]
机构：
[1] Russian Acad Sci, Saratov Sci Ctr, Inst Biochem & Physiol Plants & Microorganisms, 13 Prospekt Entuziastov, Saratov 410049, Russia
[2] RAS, Kotelnikov Inst Radio Engn & Elect, Saratov, Russia
来源：
ULTRASOUND IN MEDICINE AND BIOLOGY | 2022年 / 48卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
Viruses; Antibodies; Virus detection; Piezoelectric resonator; Electrical impedance; TRANSMISSIBLE GASTROENTERITIS VIRUS; RESPIRATORY VIRUSES; INFLUENZA-A; RT-PCR; GOLD; SENSITIVITY; MICROARRAY; ANTIBODIES; ELISA;
D O I：
10.1016/j.ultrasmedbio.2022.01.013
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
sensor system based on a piezoelectric resonator with a lateral electric field in the frequency range 6-7 MHz of the electric field for virus detection is described. Through use of the transmissible virus causing gastroenteritis in pigs and specific antibodies, the possibility of detecting the virus in suspension in real time was determined. It was found that the frequency dependence of the real and imaginary parts of the electrical impedance of such a resonator loaded with a virus suspension changes significantly after the addition of specific antibodies to the suspension. No changes are observed if the antibodies are not specific. Thus, the results obtained illustrate the possibility of detecting viruses in situ, directly in the liquid phase, if the change in the real or imaginary parts of the electrical impedance after the addition of antibodies is used as an analytical signal. The possibility of virus detection in the presence of foreign viral particles has been illustrated. (E-mail: guliy_olga@mail. ru) (C)& nbsp;2022 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
引用
收藏
页码：901 / 911
页数：11
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