Combination therapies for combating antimicrobial resistance

被引：187

作者：

Fischbach, Michael A. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Calif Inst Quantitat Biosci, San Francisco, CA 94158 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2011年 / 14卷 / 05期

关键词：

BIOSYNTHETIC GENE-CLUSTER; ANTIBIOTIC RESISTOME; DRUG-INTERACTIONS; GENOME SEQUENCE; MYCOBACTERIUM-TUBERCULOSIS; DNA GYRASE; STREPTOMYCES; EVOLUTION; SIMOCYCLINONE; ARTEMISININS;

D O I：

10.1016/j.mib.2011.08.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

New drug development strategies are needed to combat antimicrobial resistance. The object of this perspective is to highlight one such strategy: treating infections with sets of drugs rather than individual drugs. We will highlight three categories of combination therapy: those that inhibit targets in different pathways; those that inhibit distinct nodes in the same pathway; and those that inhibit the very same target in different ways. We will then consider examples of naturally occurring combination therapies produced by micro-organisms, and conclude by discussing key opportunities and challenges for making more widespread use of drug combinations.

引用

页码：519 / 523

页数：5

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