The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

被引:287
作者
Maria Rojas, Ana [1 ]
Fuentes, Gloria [2 ]
Rausell, Antonio [3 ]
Valencia, Alfonso [3 ]
机构
[1] Inst Predict & Personalized Med Canc, Computat Cell Biol Grp, Barcelona 08916, Spain
[2] ASTAR, Bioinformat Inst, Biomol Modelling & Design Div, Singapore 138671, Singapore
[3] Spanish Natl Canc Res Ctr CNIO, Struct Biol & Biocomp Programme, Madrid 28029, Spain
关键词
GTP-BINDING PROTEINS; GUANINE-NUCLEOTIDE EXCHANGE; MULTIPLE SEQUENCE ALIGNMENT; RHO GTPASES; CONFORMATIONAL TRANSITION; FUNCTIONAL SPECIFICITY; PHYLOGENETIC ANALYSIS; CRYSTAL-STRUCTURES; DNA-SEQUENCES; SAR PROTEINS;
D O I
10.1083/jcb.201103008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex relationships between the evolution of this protein superfamily sequence and the acquisition of distinct cellular functions. Together with advances in computational methods and structural studies, the sequence information has helped to identify features important for the recognition of molecular partners and the functional specialization of different members of the Ras superfamily.
引用
收藏
页码:189 / 201
页数:13
相关论文
共 83 条
[1]   A novel switch region regulates H-ras membrane orientation and signal output [J].
Abankwa, Daniel ;
Hanzal-Bayer, Michael ;
Ariotti, Nicolas ;
Plowman, Sarah J. ;
Gorfe, Alemayehu A. ;
Parton, Robert G. ;
McCammon, J. Andrew ;
Hancock, John F. .
EMBO JOURNAL, 2008, 27 (05) :727-735
[2]   Model of the Ran-RCC1 interaction using biochemical and docking experiments [J].
Azuma, Y ;
Renault, L ;
García-Ranea, JA ;
Valencia, A ;
Nishimoto, T ;
Wittinghofer, A .
JOURNAL OF MOLECULAR BIOLOGY, 1999, 289 (04) :1119-1130
[3]   RAB PROTEINS AND THEIR INTERACTION PARTNERS [J].
Barnekow, Angelika ;
Thyrock, Anika ;
Kessler, Daniel .
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 274, 2009, 274 :235-274
[4]   Effector recognition by the small GTP-binding proteins Ras and Ral [J].
Bauer, B ;
Mirey, G ;
Vetter, IR ;
García-Ranea, JA ;
Valencia, A ;
Wittinghofer, A ;
Camonis, JH ;
Cool, RH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (25) :17763-17770
[5]   Structural principles for the multispecificity of small GTP-binding proteins [J].
Biou, V ;
Cherfils, J .
BIOCHEMISTRY, 2004, 43 (22) :6833-6840
[6]   Rho GTPases and their effector proteins [J].
Bishop, AL ;
Hall, A .
BIOCHEMICAL JOURNAL, 2000, 348 (02) :241-255
[7]   Evolution of the Rho family of Ras-like GTPases in eukaryotes [J].
Boureux, Anthony ;
Vignal, Emmanuel ;
Faure, Sandrine ;
Fort, Philippe .
MOLECULAR BIOLOGY AND EVOLUTION, 2007, 24 (01) :203-216
[8]   PHYLOGENETIC ANALYSIS - MODELS AND ESTIMATION PROCEDURES [J].
CAVALLISFORZA, LL ;
EDWARDS, AWF .
EVOLUTION, 1967, 21 (03) :550-+
[9]   Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTP gamma S [J].
Cherfils, J ;
Menetrey, J ;
LeBras, G ;
LeBras, G ;
JanoueixLerosey, I ;
deGunzburg, J ;
Garel, JR ;
Auzat, I .
EMBO JOURNAL, 1997, 16 (18) :5582-5591
[10]  
Colicelli John, 2004, Sci STKE, V2004, pRE13, DOI 10.1126/stke.2502004re13