Effect of Remdesivir on mortality and length of stay in hospitalized COVID-19 patients: A single center study

被引：7

作者：

Shaikh, Quratulain ^{[1
]}

Sarfaraz, Samreen ^{[1
]}

Rahim, Anum ^{[2
]}

Hussain, Mujahid ^{[3
]}

Shah, Rabeea ^{[1
]}

Soomro, Sara ^{[1
]}

机构：

[1] Indus Hosp & Hlth Network, Dept Internal Med, Karachi, Pakistan

[2] Indus Hosp & Hlth Network, Indus Hosp Res Ctr, Karachi, Pakistan

[3] Indus Hosp & Hlth Network, Dept Pharm Serv, Karachi, Pakistan

来源：

PAKISTAN JOURNAL OF MEDICAL SCIENCES | 2022年 / 38卷 / 02期

关键词：

COVID-19; Remdesivir; mortality; ARDS;

D O I：

10.12669/pjms.38.ICON-2022.5779

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To see the difference in mortality among hospitalized COVID-19 patients given Remdesivir (RDV) with those who were not given RDV. Methods: A prospective cohort study was conducted on patients who were admitted to the COVID-19 isolation unit at The Indus Hospital, Korangi Campus Karachi between March and June 2020. Results: Groups were similar in age and gender distribution. RDV group was more hypoxic, had severe ARDS and needed higher Oxygen support compared to non-RDV group (p=0.000). Median SOFA score was 2 in RDV vs 5 in non-RDV (p=0.000). More than moderate COVID pneumonia was found in 92% of the RDV group while 89% of non-RDV group (p value=0.001). Median day of illness to administer Remdesivir was 10. There was no difference in mortality (45.5% in RDV vs 40.4% in non-RDV; p=0.4) between the two groups. Median length of hospital stay was 12 days (IQR=7.5-14.5) in RDV group compared to 10 days (IQR=6-14) in non-RDV group (p=0.009). Conclusion: RDV did not show any difference in in-hospital mortality in our patients. More patients had severe ARDS in the RDV group while patients in the non-RDV group had higher SOFA score and multi-organ failure. Length of stay was longer in patients receiving Remdesivir.

引用

页码：405 / 410

页数：6

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