Remote control of cellular behaviour with magnetic nanoparticles

被引:422
作者
Dobson, Jon [1 ]
机构
[1] Keele Univ, Inst Sci & Technol Med, Stoke On Trent ST9 9EZ, Staffs, England
关键词
D O I
10.1038/nnano.2008.39
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
By binding magnetic nanoparticles to the surface of cells, it is possible to manipulate and control cell function with an external magnetic field. The technique of activating cells with magnetic nanoparticles offers a means to isolate and explore cellular mechanics and ion channel activation to gain better understanding of these processes. Here, we go beyond using this technique as an investigative tool and focus on its potential to actively control cellular functions and processes with an eye towards biological and clinical applications. In particular, we focus on applications in tissue engineering and regenerative medicine.
引用
收藏
页码:139 / 143
页数:5
相关论文
共 47 条
  • [1] Magnetically-guided self-assembly of fibrin matrices with ordered nano-scale structure for tissue engineering
    Alsberg, Eben
    Feinstein, Efraim
    Joy, M. P.
    Prentiss, Mara
    Ingber, Donald E.
    [J]. TISSUE ENGINEERING, 2006, 12 (11): : 3247 - 3256
  • [2] [Anonymous], COMP BIOCH PHYSL A
  • [3] Measurement of local viscoelasticity and forces in living cells by magnetic tweezers
    Bausch, AR
    Möller, W
    Sackmann, E
    [J]. BIOPHYSICAL JOURNAL, 1999, 76 (01) : 573 - 579
  • [4] Rapid stiffening of integrin receptor-actin linkages in endothelial cells stimulated with thrombin: A magnetic bead microrheology study
    Bausch, AR
    Hellerer, U
    Essler, M
    Aepfelbacher, M
    Sackmann, E
    [J]. BIOPHYSICAL JOURNAL, 2001, 80 (06) : 2649 - 2657
  • [5] Functionalisation of magnetic nanoparticles for applications in biomedicine
    Berry, CC
    Curtis, ASG
    [J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) : R198 - R206
  • [6] Cartmell Sarah H, 2002, IEEE Trans Nanobioscience, V1, P92, DOI 10.1109/TNB.2002.806945
  • [7] Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly
    Cavalcanti-Adam, EA
    Micoulet, A
    Blümmel, J
    Auernheimer, J
    Kessler, H
    Spatz, JP
    [J]. EUROPEAN JOURNAL OF CELL BIOLOGY, 2006, 85 (3-4) : 219 - 224
  • [8] Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands
    Cavalcanti-Adam, Elisabetta Ada
    Volberg, Tova
    Micoulet, Alexandre
    Kessler, Horst
    Geiger, Benjamin
    Spatz, Joachim Pius
    [J]. BIOPHYSICAL JOURNAL, 2007, 92 (08) : 2964 - 2974
  • [9] THE PHYSICAL PROPERTIES OF CYTOPLASM - A STUDY BY MEANS OF THE MAGNETIC PARTICLE METHOD .1. EXPERIMENTAL
    CRICK, FHC
    HUGHES, AFW
    [J]. EXPERIMENTAL CELL RESEARCH, 1950, 1 (01) : 37 - 80
  • [10] DOBSON J, 2002, EUR CELLS MAT S2, V4, P130