Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition

被引：25

作者：

Cao, Xiaohui ^{[1
]}

Wang, Ge ^{[1
]}

Zhang, Richeng ^{[1
]}

Wei, Yingying ^{[1
]}

Wang, Wei ^{[1
]}

Sun, Huichao ^{[1
]}

Chen, Ligong ^{[1
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 19期

关键词：

ORGANIC CATALYSTS; ACID CATALYSTS; IONIC-LIQUID; KETONES; ALDEHYDES; EFFICIENT; NITROOLEFINS; PEPTIDES; ALDOL; NITROSTYRENES;

D O I：

10.1039/c1ob05679d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel proline-based reduced dipeptides was developed and evaluated for a direct Michael addition of ketones and aldehydes to nitroalkenes. Excellent yields (up to 95%), diastereoselectivities (up to 98% dr) and enantioselectivities (up to 98% ee) were achieved in the presence of 5 mol% catalyst without any additional additives at room temperature.

引用

页码：6487 / 6490

页数：4

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