Antifouling metabolites from the mangrove plant Ceriops tagal

被引：44

作者：

De Chen, Jun ^{[1
]}

Feng, Dan Qin ^{[2
]}

Yang, Zhi Wei ^{[1
]}

Wang, Zhan Chang ^{[1
]}

Qiu, Yan ^{[3
]}

Lin, Yi Ming ^{[1
]}

机构：

[1] Xiamen Univ, Dept Biol, Sch Life Sci, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Oceanog & Environm Sci, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Dept Pharm, Sch Med, Xiamen 361005, Peoples R China

来源：

MOLECULES | 2008年 / 13卷 / 02期

关键词：

diterpenes; antifouling activity; barnacle; Ceriops tagal;

D O I：

10.3390/molecules13020212

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The new diterpene methoxy-ent-8(14)-pimarenely-15-one ( 1) and three known metabolites: ent-8(14)-pimarene-15R, 16-diol(2), stigmasterol ( 3) and beta-sitosterol ( 4), were isolated from the roots of the mangrove plant Ceriops tagal. Their structures and relative stereochemistry were elucidated by means of extensive NMR, IR and MS analysis. Compounds 1, 2, 3 and 4 exhibited significant antifouling activities against cyprid larvae of the barnacle Balanus albicostatus Pilsbry, with EC50 values of 0.32 +/- 0.01, 0.04 +/- 0.00, 4.05 +/- 0.15 and 18.47 +/- 0.40 mu g/cm(2), respectively, whereas their toxicities towards cyprids were very low, with LC50 values all above 10 mu g/cm(2).

引用

页码：212 / 219

页数：8

共 18 条

[1] Modern approaches to marine antifouling coatings [J].

Chambers, L. D. ;

Stokes, K. R. ;

Walsh, F. C. ;

Wood, R. J. K. .

SURFACE & COATINGS TECHNOLOGY, 2006, 201 (06) :3642-3652

[2] Marine natural product antifoulants: Status and potential [J].

Clare, AS .

BIOFOULING, 1996, 9 (03) :211-229

[3] NEW DANGEROUS CHEMICALS IN THE ENVIRONMENT - LESSONS FROM TBT [J].

ELLIS, DV .

MARINE POLLUTION BULLETIN, 1991, 22 (01) :8-10

[4] TRIMMED SPEARMAN-KARBER METHOD FOR ESTIMATING MEDIAN LETHAL CONCENTRATIONS IN TOXICITY BIOASSAYS [J].

HAMILTON, MA ;

RUSSO, RC ;

THURSTON, RV .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1977, 11 (07) :714-719

[5] CORRECTION [J].

HAMILTON, MA .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1978, 12 (04) :417-417

[6]

Han L, 2005, PHARMAZIE, V60, P705

[7]

Lai AR, 1990, PHYTOCHEMISTRY, V29, P2239

[8] ent-Pimarane derivatives from Dysoxylum hainanense [J].

Luo, XD ;

Wu, SH ;

Ma, YB ;

Wu, DG .

PHYTOCHEMISTRY, 2001, 57 (01) :131-134

[9] Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype [J].

Ma, GX ;

Wang, TS ;

Yin, L ;

Pan, Y ;

Guo, YL ;

LeBlanc, GA ;

Reinecke, MG ;

Watson, WH ;

Krawiec, M .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (01) :112-115

[10]

Richmond M.D., 1991, Biofouling, V3, P151

← 1 2 →