Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

被引：179

作者：

Brisson, Lucie ^{[1
]}

Banski, Piotr ^{[1
]}

Sboarina, Martina ^{[1
]}

Dethier, Coralie ^{[1
]}

Danhier, Pierre ^{[1
,2
]}

Fontenille, Marie-Josephine ^{[1
]}

Van Hee, Vincent F. ^{[1
]}

Vazeille, Thibaut ^{[1
]}

Tardy, Morgane ^{[1
]}

Falces, Jorge ^{[1
]}

Bouzin, Caroline ^{[3
]}

Porporato, Paolo E. ^{[1
]}

Frederick, Raphael ^{[2
]}

Michiels, Carine ^{[4
]}

Copetti, Tamara ^{[1
]}

Sonveaux, Pierre ^{[1
]}

机构：

[1] Catholic Univ Louvain, Pole Pharmacol, Inst Rech Expt & Clin, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, Belgium

[3] Catholic Univ Louvain, IREC Imaging Platform, B-1200 Brussels, Belgium

[4] Univ Namur, URBC NARILIS, B-5000 Namur, Belgium

来源：

CANCER CELL | 2016年 / 30卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

BREAST-CANCER; CELL-DEATH; TUMOR-CELLS; H SUBUNIT; EXPRESSION; PROTEIN; MITOCHONDRIAL; CHLOROQUINE; GROWTH; ANGIOGENESIS;

D O I：

10.1016/j.ccell.2016.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metabolic adaptability is essential for tumor progression and includes cooperation between cancer cells with different metabolic phenotypes. Optimal glucose supply to glycolytic cancer cells occurs when oxidative cancer cells use lactate preferentially to glucose. However, using lactate instead of glucose mimics glucose deprivation, and glucose starvation induces autophagy. We report that lactate sustains autophagy in cancer. In cancer cells preferentially to normal cells, lactate dehydrogenase B (LDHB), catalyzing the conversion of lactate and NAD(+) to pyruvate, NADH and H+, controls lysosomal acidification, vesicle maturation, and intracellular proteolysis. LDHB activity is necessary for basal autophagy and cancer cell proliferation not only in oxidative cancer cells but also in glycolytic cancer cells.

引用

页码：418 / 431

页数：14

共 67 条

[1] SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis [J].

Aguirre-Gamboa, Raul ;

Gomez-Rueda, Hugo ;

Martinez-Ledesma, Emmanuel ;

Martinez-Torteya, Antonio ;

Chacolla-Huaringa, Rafael ;

Rodriguez-Barrientos, Alberto ;

Tamez-Pena, Jose G. ;

Trevino, Victor .

PLOS ONE, 2013, 8 (09)

[2] Principles and Current Strategies for Targeting Autophagy for Cancer Treatment [J].

Amaravadi, Ravi K. ;

Lippincott-Schwartz, Jennifer ;

Yin, Xiao-Ming ;

Weiss, William A. ;

Takebe, Naoko ;

Timmer, William ;

DiPaola, Robert S. ;

Lotze, Michael T. ;

White, Eileen .

CLINICAL CANCER RESEARCH, 2011, 17 (04) :654-666

[3] Novel adjuvants from seaweed impede autophagy signaling in therapy-resistant residual pancreatic cancer [J].

Aravindan, Sheeja ;

Ramraj, Satish Kumar ;

Somasundaram, Somasundaram T. ;

Aravindan, Natarajan .

JOURNAL OF BIOMEDICAL SCIENCE, 2015, 22

[4] Tumor Suppression and Promotion by Autophagy [J].

Avalos, Yenniffer ;

Canales, Jimena ;

Bravo-Sagua, Roberto ;

Criollo, Alfredo ;

Lavandero, Sergio ;

Quest, Andrew F. G. .

BIOMED RESEARCH INTERNATIONAL, 2014, 2014

[5] RNAi screens in mice identify physiological regulators of oncogenic growth [J].

Beronja, Slobodan ;

Janki, Peter ;

Heller, Evan ;

Lien, Wen-Hui ;

Keyes, Brice E. ;

Oshimori, Naoki ;

Fuchs, Elaine .

NATURE, 2013, 501 (7466) :185-+

[6] The V-type H+ ATPase:: molecular structure and function, physiological roles and regulation [J].

Beyenbach, KW ;

Wieczorek, H .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2006, 209 (04) :577-589

[7] Temozolomide Modifies Caveolin-1 Expression in Experimental Malignant Gliomas In Vitro and In Vivo [J].

Bruyere, Celine ;

Abeloos, Laurence ;

Lamoral-Theys, Delphine ;

Senetta, Rebecca ;

Mathieu, Veronique ;

Le Mercier, Marie ;

Kast, Richard E. ;

Cassoni, Paola ;

Vandenbussche, Guy ;

Kiss, Robert ;

Lefranc, Florence .

TRANSLATIONAL ONCOLOGY, 2011, 4 (02) :92-100

[8] Role and regulation of autophagy in cancer [J].

Chen, Ning ;

Karantza-Wadsworth, Vassiliki .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2009, 1793 (09) :1516-1523

[9] Autophagy is a therapeutic target in anticancer drug resistance [J].

Chen, Suning ;

Rehman, Sumaiyah K. ;

Zhang, Wei ;

Wen, Aidong ;

Yao, Libo ;

Zhang, Jian .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2010, 1806 (02) :220-229

[10] Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation [J].

Ciccia, Francesco ;

Accardo-Palumbo, Antonina ;

Rizzo, Aroldo ;

Guggino, Giuliana ;

Raimondo, Stefania ;

Giardina, AnnaRita ;

Cannizzaro, Alessandra ;

Colbert, Robert A. ;

Alessandro, Riccardo ;

Triolo, Giovanni .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (08) :1566-1574

← 1 2 3 4 5 6 7 →