α-opic flux models based on the five fundus photoreceptors for prediction of light-induced melatonin suppression

被引：3

作者：

Nie, Jingxin ^{[1
]}

Chen, Zhizhong ^{[1
,6
,7
]}

Jiao, Fei ^{[1
,2
]}

Chen, Yiyong ^{[1
]}

Pan, Zuojian ^{[1
]}

Deng, Chuhan ^{[1
]}

Zhang, Haodong ^{[1
]}

Dong, Boyan ^{[1
]}

Xi, Xin ^{[1
]}

Kang, Xiangning ^{[1
]}

Wang, Qi ^{[3
]}

Dang, Weimin ^{[4
]}

Dong, Wentian ^{[4
]}

Zhou, Tianhang ^{[4
]}

Zhou, Shuzhe ^{[4
]}

Yu, Xin ^{[4
]}

Tong, Yuzhen ^{[1
,5
]}

Zhang, Guoyi ^{[1
,3
]}

Shen, Bo ^{[1
]}

机构：

[1] Peking Univ, Sch Phys, State Key Lab Artificial Microstruct & Mesoscop Ph, Beijing 100871, Peoples R China

[2] Peking Univ, Sch Phys, State Key Lab Nucl Phys & Technol, Beijing 100871, Peoples R China

[3] Peking Univ, Dongguan Inst Optoelect, Dongguan 523808, Guangdong, Peoples R China

[4] Peking Univ, Peking Univ Hosp 6, Peking Univ Inst Mental Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China

[5] Res Ctr Wide Bandgap Semicond PKU, Gaoan 330800, Jiangxi, Peoples R China

[6] Peking Univ, Yangtze Delta Inst Optoelect, Nantong 226000, Jiangsu, Peoples R China

[7] Peking Univ, Sch Phys, State Key Lab Artificial Microstruct & Mesoscop Ph, 209,Chengfu Rd, Beijing 100871, Peoples R China

来源：

BUILDING AND ENVIRONMENT | 2022年 / 226卷

关键词：

Circadian rhythm; Melatonin suppression; -opic flux models; Light environment; POLYCHROMATIC-LIGHT; NONVISUAL RESPONSES; ACTION SPECTRUM; WAVELENGTH; SENSITIVITY; MELANOPSIN; ALERTNESS; HUMANS; SYSTEM; BLUE;

D O I：

10.1016/j.buildenv.2022.109767

中图分类号：

TU [建筑科学];

学科分类号：

0813 ;

摘要：

Light is effective to suppress the melatonin and affects the non-visual responses. The relationship between light conditions and melatonin suppression is significant when designing light environments. Based on the alpha-opic illuminances of five fundus photoreceptors, various previous models are built to fit and predict the experimental melatonin suppression. In this study, we present models based on alpha-opic fluxes, which are products of alpha-opic illuminances and pupil areas, to improve the fitting results of the experimental melatonin suppression. For 30 -and 90-min light exposures, the alpha-opic flux models present higher adjusted R-squared and lower root mean square of error (RMSE) when fitting the experimental melatonin suppression, regardless of pupil dilation or not. The alpha-opic flux models also explain the spectral opponency on melatonin suppression. According to the residuals between predicable and experimental melatonin suppression, the effects of pupil dilation, type of light source, and subject's age are further discussed. The subject's age has little effect on the melatonin suppression. The alpha-opic flux models decrease the fitting residuals under different conditions, improving the applicability of the fitting models on melatonin suppression.

引用

页数：12

共 62 条

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