COVID-19 vaccine uptake, effectiveness, and waning in 82,959 health care workers: A national prospective cohort study in Wales

被引：30

作者：

Bedston, Stuart ^{[1
]}

Akbari, Ashley ^{[1
]}

Jarvis, Christopher I. ^{[2
]}

Lowthian, Emily ^{[1
]}

Torabi, Fatemeh ^{[1
]}

North, Laura ^{[1
]}

Lyons, Jane ^{[1
]}

Perry, Malorie ^{[3
]}

Griffiths, Lucy J. ^{[1
]}

Owen, Rhiannon K. ^{[1
]}

Beggs, Jillian ^{[4
]}

Chuter, Antony ^{[4
]}

Bradley, Declan T. ^{[5
]}

de Lusignan, Simon ^{[6
]}

Fry, Richard ^{[1
]}

Hobbs, F. D. Richard ^{[7
]}

Hollinghurst, Joe ^{[1
]}

Katikireddi, Srinivasa Vittal ^{[7
]}

Murphy, Siobhan ^{[5
]}

O'Reily, Dermot ^{[5
]}

Robertson, Chris ^{[8
,9
]}

Shi, Ting ^{[10
]}

Tsang, Ruby S. M. ^{[6
]}

Sheikh, Aziz ^{[11
,12
]}

Lyons, Ronan A. ^{[1
]}

机构：

[1] Swansea Univ, Sch Med, Populat Data Sci, Data Sci Bldg,Singleton Pk, Swansea SA2 8PP, W Glam, Wales

[2] London Sch Hyg & Trop Med, London, England

[3] Publ Hlth Wales, Vaccine Preventable Dis Programme, Cardiff, Wales

[4] Patient & Publ Involvement PPI BREATHE Hlth Data, London, England

[5] Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

[6] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England

[7] Univ Glasgow, MRC CSO Social & Publ Hlth Sci Unit, Glasgow, Lanark, Scotland

[8] Strathclyde Univ, Dept Math & Stat, Glasgow, Lanark, Scotland

[9] Publ Hlth Scotland, Edinburgh, Midlothian, Scotland

[10] Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland

[11] Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland

[12] Univ Edinburgh, HDR UK BREATHE Hub, Edinburgh, Midlothian, Scotland

来源：

VACCINE | 2022年 / 40卷 / 08期

基金：

英国科研创新办公室; 英国经济与社会研究理事会; 英国工程与自然科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

COVID-19; Health care workers; Vaccines; Pandemic; INFECTION; SCOTLAND;

D O I：

10.1016/j.vaccine.2021.11.061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: While population estimates suggest high vaccine effectiveness against SARS-CoV-2 infection, the protection for health care workers, who are at higher risk of SARS-CoV-2 exposure, is less understood. Methods: We conducted a national cohort study of health care workers in Wales (UK) from 7 December 2020 to 30 September 2021. We examined uptake of any COVID-19 vaccine, and the effectiveness of BNT162b2 mRNA (Pfizer-BioNTech) against polymerase chain reaction (PCR) confirmed SARS-CoV-2 infection. We used linked and routinely collected national-scale data within the SAIL Databank. Data were available on 82,959 health care workers in Wales, with exposure extending to 26 weeks after second doses. Results: Overall vaccine uptake was high (90%), with most health care workers receiving the BNT162b2 vaccine (79%). Vaccine uptake differed by age, staff role, socioeconomic status; those aged 50-59 and 60+ years old were 1.6 times more likely to get vaccinated than those aged 16-29. Medical and dental staff, and Allied Health Practitioners were 1.5 and 1.1 times more likely to get vaccinated, compared to nursing and midwifery staff. The effectiveness of the BNT162b2 vaccine was found to be strong and consistent across the characteristics considered; 52% three to six weeks after first dose, 86% from two weeks after second dose, though this declined to 53% from 22 weeks after the second dose. Conclusions: With some variation in rate of uptake, those who were vaccinated had a reduced risk of PCRconfirmed SARS-CoV-2 infection, compared to those unvaccinated. Second dose has provided stronger protection for longer than first dose but our study is consistent with waning from seven weeks onwards. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).

引用

页码：1180 / 1189

页数：10

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