A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

被引：152

作者：

Wu, Bin ^{[1
]}

Ong, Michelle S. ^{[1
]}

Groessl, Michael ^{[2
]}

Adhireksan, Zenita ^{[1
]}

Hartinger, Christian G. ^{[1
,3
]}

Dyson, Paul J. ^{[2
]}

Davey, Curt A.

机构：

[1] Nanyang Technol Univ, Sch Biol Sci, Div Struct & Computat Biol, Singapore 637551, Singapore

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[3] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 13期

关键词：

bioinorganic chemistry; cancer; histone binding; nucleosomes; RAPTA-C; ruthenium; ANTICANCER METALLODRUGS; MASS-SPECTROMETRY; COMPLEXES; CHROMATIN; BINDING; DNA; INHIBITION; CISPLATIN; DRUGS;

D O I：

10.1002/chem.201100298

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

His-tones are not ruth-less: A ruthenium anticancer agent, RAPTA-C, was found to associate with chromatin in cancer cells and to form stable, well-defined adducts in the nucleosome core at specific histone protein sites (see picture). This illuminates the macromolecular binding properties of this antimetastasis agent and indicates potential for developing metallodrugs for site-selective targeting of chromatin. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3562 / 3566

页数：5

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