Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins

被引：261

作者：

Shier, WT ^{[1
]}

Shier, AC

Xie, W

Mirocha, CJ

机构：

[1] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Plant Pathol, Minneapolis, MN 55455 USA

来源：

TOXICON | 2001年 / 39卷 / 09期

关键词：

zearalenone; estrogenicity; estradiol; Fusarium mycotoxins; structure-activity relationships;

D O I：

10.1016/S0041-0101(00)00259-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Zearalenones are estrogenic Fusarium mycotoxins consisting of a resorcinol moiety fused to a 14-member macrocyclic lactone. Using an improved MCF7 human breast cell proliferation assay, we have compared the estrogenicity of 17 chromatographically-homogeneous zearalenones. Both similarities and substantial differences from published results in intact animal systems were observed. Substantial human estrogenicity was retained even in analogs lacking hydroxylation on the aromatic and macrocyclic rings. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1435 / 1438

页数：4

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