The Contribution of Interleukin-8 Rs4073 Genotypes to Triple Negative Breast Cancer Risk in Taiwan

被引：10
作者：
Wang, Yun-Chi [1 ,2 ]
Wang, Zhi-Hong [3 ]
Yen, Jung-Hsing [4 ,5 ]
Shen, Yi-Cheng [2 ]
Shen, Te-Chun [2 ]
Chang, Wen -Shin [1 ,2 ]
Su, Chen-Hsien [2 ]
Chen, Kai-Yuan [6 ]
Yen, Chun-Ming [6 ]
Lee, Hsu-Tung [6 ]
Yang, Jai -Sing [7 ]
Bau, Da-Tian [1 ,2 ,8 ,9 ]
Tsai, Chia-Wen [1 ,2 ,9 ]
机构：
[1] China Med Univ, Grad Inst Biomed Sci, ROC, Taichung, Taiwan
[2] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, Taichung, Taiwan
[3] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan
[4] Taichung Vet Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taichung, Taiwan
[5] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[6] Taichung Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Taichung, Taiwan
[7] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan
[8] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan
[9] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, 2 Yuh-Der Rd, Taichung 404, Taiwan
来源：
ANTICANCER RESEARCH | 2022年 / 42卷 / 08期
关键词：
Breast cancer; genotype; interleukin-8; polymorphism; Taiwan; GENE POLYMORPHISMS; CARCINOMA CELLS; POOR-PROGNOSIS; GASTRIC-CANCER; EXPRESSION; ASSOCIATION; IL-8; PROGRESSION; RECEPTORS; METASTASIS;
D O I：
10.21873/anticanres.15870
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Triple negative breast cancer (TNBC) is one of the most challenging breast cancer types. Interleukin-8 (IL-8) is a pro-tumorigenic cytokine, promoting tumor proliferation and migration. This study aimed to examine the contribution of IL-8 rs4073 genotypes to breast cancer risk and provide a summary of related literature. Materials and Methods: IL-8 genotypic profiles were determined among 1,232 breast cancer cases and 1,232 controls via polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The IL-8 rs4073 AT and AA genotypes had significantly lower prevalence in the case group compared to control group. Allelic frequency analysis showed that individuals carrying the A allele have relatively decreased risk for breast cancer. The stratification analysis showed that IL-8 rs4073 genotypes were protective markers for those with younger (<= 55) age. Conclusion: IL-8 rs4073 A allele is a novel predictor for breast cancer, especially TNBC.
引用
收藏
页码：3799 / 3806
页数：8
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