Structural studies of Cu(II) binding to the novel peptidyl derivative of quinoxaline: N-(3-(2,3-di(pyridin-2-yl)quinoxalin-6-yl)alanyl)glycine

被引：5
|
作者：
Szczepanik, W. [1 ]
Mlynarz, P. [2 ]
Stefanowicz, P. [1 ]
Kucharczyk-Klaminska, M. [1 ]
D'Amelio, N. [3 ]
Olbert-Majkut, A. [1 ]
Staszewska, A. [1 ]
Ratajska, M. [1 ]
Szewczuk, Z. [1 ]
Jezowska-Bojczuk, M. [1 ]
机构：
[1] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland
[2] Wroclaw Univ Technol, Dept Chem, PL-50370 Wroclaw, Poland
[3] Bracco Imaging CRB Trieste Area Sci Pk, I-34149 Basovizza Trieste, Italy
来源：
POLYHEDRON | 2011年 / 30卷 / 01期
关键词：
Cu(II) complexes; Heterocycles; Pyridyl; Dipeptides; Conjugates; Head-to-tail dimer; TYROSINE-CONTAINING DIPEPTIDES; CRYSTAL-STRUCTURE; PALLADIUM(II) COMPLEXES; PLATINUM(II) COMPLEXES; COPPER(II) COMPLEXES; DNA; ACID; CLEAVAGE; LIGANDS; DPQ;
D O I：
10.1016/j.poly.2010.09.020
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The coordination properties of the novel conjugate towards copper ions were investigated. The performed studies exhibited the unusual binding properties of the ligand molecule having two potential strong coordination sites, namely dipeptidic chain and pyridyl nitrogens. On the basis of potentiometric and spectroscopic studies the binding at the low pH values to the aromatic entity is suggested, while the rise of pH (including physiological one) yielded the dimeric head-to-tail complex formation. This stable species possesses three nitrogen donors involved in Cu(II) chelation: N(pirydyl), NH2 and N-(amide). (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9 / 15
页数：7
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