A Prion-like Trigger of Antiviral Signaling

被引：10

作者：

Ye, Junqiang ^{[1
]}

Maniatis, Tom ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

CELL | 2011年 / 146卷 / 03期

关键词：

LONG-TERM FACILITATION; NF-KAPPA-B; ACTIVATION; PROTEIN; APLYSIA; CPEB; IRF3;

D O I：

10.1016/j.cell.2011.07.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antiviral signaling.

引用

页码：348 / 350

页数：3

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