A Comparative Analysis Shows Morphofunctional Differences between the Rat and Mouse Melanin-Concentrating Hormone Systems

被引：46

作者：

Croizier, Sophie ^{[1
]}

Franchi-Bernard, Gabrielle ^{[1
]}

Colard, Claude ^{[1
]}

Poncet, Fabrice ^{[1
]}

La Roche, Annie ^{[1
]}

Risold, Pierre-Yves ^{[1
]}

机构：

[1] Univ Franche Comte, Fac Med & Pharmacie, F-25030 Besancon, France

来源：

PLOS ONE | 2010年 / 5卷 / 11期

关键词：

HYPOCRETIN/OREXIN-CONTAINING NEURONS; LATERAL DORSAL HYPOTHALAMUS; RECEPTOR-DEFICIENT MICE; VENTRAL DIENCEPHALON; EXPRESSION PATTERNS; MCH NEURONS; PEPTIDE; PROJECTIONS; BRAIN; TIME;

D O I：

10.1371/journal.pone.0015471

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sub-populations of neurons producing melanin-concentrating hormone (MCH) are characterized by distinct projection patterns, birthdates and CART/NK3 expression in rat. Evidence for such sub-populations has not been reported in other species. However, given that genetically engineered mouse lines are now commonly used as experimental models, a better characterization of the anatomy and morphofunctionnal organization of MCH system in this species is then necessary. Combining multiple immunohistochemistry experiments with in situ hybridization, tract tracing or BrdU injections, evidence supporting the hypothesis that rat and mouse MCH systems are not identical was obtained: sub-populations of MCH neurons also exist in mouse, but their relative abundance is different. Furthermore, divergences in the distribution of MCH axons were observed, in particular in the ventromedial hypothalamus. These differences suggest that rat and mouse MCH neurons are differentially involved in anatomical networks that control feeding and the sleep/wake cycle.

引用

页数：12

共 45 条

[11] PROJECTIONS OF THE VENTRAL PREMAMMILLARY NUCLEUS [J].

CANTERAS, NS ;

SIMERLY, RB ;

SWANSON, LW .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 324 (02) :195-212

[12] Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity [J].

Chen, YY ;

Hu, CZ ;

Hsu, CK ;

Zhang, Q ;

Bi, C ;

Asnicar, M ;

Hsiung, HM ;

Fox, N ;

Slieker, LJ ;

Yang, DD ;

Heiman, ML ;

Shi, YG .

ENDOCRINOLOGY, 2002, 143 (07) :2469-2477

[13] The melanin-concentrating hormone system modulates cocaine reward [J].

Chung, Shinjae ;

Hopf, F. Woodward ;

Nagasaki, Hiroshi ;

Li, Chun-Ying ;

Belluzzi, James D. ;

Bonci, Antonello ;

Civelli, Olivier .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (16) :6772-6777

[14] Characterization of subpopulations of neurons producing melanin-concentrating hormone in the rat ventral diencephalon [J].

Cvetkovic, V ;

Brischoux, F ;

Jacquemard, C ;

Fellmann, D ;

Griffond, B ;

Risold, PY .

JOURNAL OF NEUROCHEMISTRY, 2004, 91 (04) :911-919

[15] Evidence of melanin-concentrating hormone-containing neurons supplying both cortical and neuroendocrine projections [J].

Cvetkovic, V ;

Brischoux, F ;

Griffond, B ;

Bernard, G ;

Jacquemard, C ;

Fellmann, D ;

Risold, PY .

NEUROSCIENCE, 2003, 116 (01) :31-35

[16] CLONING OF CDNAS ENCODING A RAT NEUROPEPTIDE IMMUNOLOGICALLY RELATED TO SALMON MELANIN-CONCENTRATING HORMONE [J].

FELLMANN, D ;

BRESSON, JL ;

BRETON, C ;

BAHJAOUI, M ;

ROUILLON, A ;

GOUGET, A ;

BUGNON, C .

NEUROSCIENCE LETTERS, 1989, 106 (1-2) :23-28

FELLMANN, D ;

BUGNON, C ;

RISOLD, PY .

NEUROSCIENCE LETTERS, 1987, 74 (03) :275-280

[18]

Gerfen C. R., 1996, Handbook of chemical neuroanatomy, V12, P371, DOI [10.1016/S0924-8196(96)80004-2, DOI 10.1016/S0924-8196(96)80004-2]

[19]

Griffond B, 2002, INT REV CYTOL, V213, P233

[20] MCH and feeding behavior-interaction with peptidic network [J].

Griffond, B. ;

Risold, P. Y. .

PEPTIDES, 2009, 30 (11) :2045-2051

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