Metabolomics in the developmental origins of obesity and its cardiometabolic consequences

被引：47

作者：

Hivert, M. F. ^{[1
,2
,3
]}

Perng, W. ^{[1
,2
]}

Watkins, S. M. ^{[4
]}

Newgard, C. S. ^{[5
]}

Kenny, L. C. ^{[6
]}

Kristal, B. S. ^{[7
,8
]}

Patti, M. E. ^{[9
]}

Isganaitis, E. ^{[9
]}

DeMeo, D. L. ^{[10
,11
]}

Oken, E. ^{[1
,2
,12
]}

Gillman, M. W. ^{[1
,2
,12
]}

机构：

[1] Harvard Univ, Sch Med, Dept Populat Med, Obes Prevent Program, Boston, MA 02215 USA

[2] Harvard Pilgrim Hlth Care Inst, Boston, MA 02215 USA

[3] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[4] Metabolon Inc, West Sacramento, CA USA

[5] Duke Univ Med, Nutr & Metab Ctr, Durham, NC USA

[6] Univ Coll Cork, Irish Ctr Fetal & Neonatal Translat Res, Cork, Ireland

[7] Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Boston, MA USA

[9] Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

[10] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA

[11] Brigham & Womens Hosp, Div Pulm & Crit Care, Boston, MA 02115 USA

[12] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

来源：

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE | 2015年 / 6卷 / 02期

基金：

美国国家卫生研究院;

关键词：

DOHaD; metabolic profiling; metabolomics; obesity; TRIMESTER AMNIOTIC-FLUID; LIQUID-CHROMATOGRAPHY; METABOLICALLY HEALTHY; INSULIN-RESISTANCE; MASS SPECTROMETRY; HEART-DISEASE; NMR; SERUM; PLASMA; BLOOD;

D O I：

10.1017/S204017441500001X

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In this review, we discuss the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD). We first provide an overview of common techniques and analytical approaches to help interested investigators dive into this relatively novel field. Next, we describe how metabolomics may capture exposures that are notoriously difficult to quantify, and help to further refine phenotypes associated with excess adiposity and related metabolic sequelae over the life course. Together, these data can ultimately help to elucidate mechanisms that underlie fetal metabolic programming. Finally, we review current gaps in knowledge and identify areas where the field of metabolomics is likely to provide insights into mechanisms linked to DOHaD in human populations.

引用

页码：65 / 78

页数：14

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