Oligonucleotide libraries - variatio delectat

被引：54
作者：
Famulok, M [1 ]
Jenne, A [1 ]
机构：
[1] Univ Munich, Inst Biochem, D-81377 Munich, Germany
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 03期
关键词：
D O I：
10.1016/S1367-5931(98)80004-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In vitro selection of combinatorial nucleic acid libraries leads to specific target-binding molecules - RNA, single stranded DNA, modified RNA or modified DNA, commonly designated as aptamers - and to novel catalytic nucleic acids. The current state of aptamer and ribozyme technology is such that it establishes itself as a means of obtaining useful tools for molecular biology, diagnostics, molecular medicine and bio-organic chemistry.
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页码：320 / 327
页数：8
相关论文
共 69 条
[1]   Protective effects of an aptamer inhibitor of neutrophil elastase in lung inflammatory injury [J].
Bless, NM ;
Smith, D ;
Charlton, J ;
Czermak, BJ ;
Schmal, H ;
Friedl, HP ;
Ward, PA .
CURRENT BIOLOGY, 1997, 7 (11) :877-880
[2]   In vitro selection of catalytic polynucleotides [J].
Breaker, RR .
CHEMICAL REVIEWS, 1997, 97 (02) :371-390
[3]   DNA enzymes [J].
Breaker, RR .
NATURE BIOTECHNOLOGY, 1997, 15 (05) :427-431
[4]   DNA aptamers and DNA enzymes [J].
Breaker, RR .
CURRENT OPINION IN CHEMICAL BIOLOGY, 1997, 1 (01) :26-31
[5]   Single-stranded RNA recognition by the bacteriophage T4 translational repressor, RegA [J].
Brown, D ;
Brown, J ;
Kang, CH ;
Gold, L ;
Allen, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (23) :14969-14974
[6]   The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo [J].
Buckanovich, RJ ;
Darnell, RB .
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (06) :3194-3201
[7]  
BURGSTALLER P, 1998, ORGANIC SYNTHESIS HI, V3
[8]   RNA aptamers to the peptidyl transferase inhibitor chloramphenicol [J].
Burke, DH ;
Hoffman, DC ;
Brown, A ;
Hansen, M ;
Pardi, A ;
Gold, L .
CHEMISTRY & BIOLOGY, 1997, 4 (11) :833-843
[9]   Cofactor-assisted self-cleavage in DNA libraries with a 3'-5'-phosphoramidate bond [J].
Burmeister, J ;
vonKiedrowski, G ;
Ellington, AD .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (12) :1321-1324
[10]   Highly potent irreversible inhibitors of neutrophil elastase generated by selection from a randomized DNA-valine phosphonate library [J].
Charlton, J ;
Kirschenheuter, GP ;
Smith, D .
BIOCHEMISTRY, 1997, 36 (10) :3018-3026
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