Crystal structure of Rv3899c184-410, a hypothetical protein from Mycobacterium tuberculosis

被引：3
|
作者：
Liu, Yingying [1 ]
Gao, Yunrong [2 ,3 ]
Li, Defeng [2 ,3 ]
Fleming, Joy [2 ,3 ]
Li, Honglin [1 ]
Bi, Lijun [1 ,2 ,3 ]
机构：
[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, 15 Datun Rd, Beijing 100101, Peoples R China
[3] Chinese Acad Sci, Inst Biophys, Lab Noncoding RNA, 15 Datun Rd, Beijing 100101, Peoples R China
来源：
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS | 2016年 / 72卷
基金：
中国国家自然科学基金;
关键词：
Mycobacterium tuberculosis; Rv3899c(184-410); crystal structure; CALMETTE; FEATURES;
D O I：
10.1107/S2053230X16010943
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; however, its biological function is unknown. Here, the global structure of Rv3899c(184-410), a fragment of Rv3899c, is reported. The structure resembles the shell of a sea snail, and its N- and C-termini form two relatively independent compact domains: an alpha/beta/alpha sandwich folding domain and an alpha-helix bundle domain. There are no reported protein structures for any Rv3899c homologues; this structure provides the first structural glimpse of a new protein family consisting of Rv3899c and its homologues.
引用
收藏
页码：642 / 645
页数：4
相关论文
共 50 条
  • [21] Crystal structure of Mycobacterium tuberculosis Rv0760c at 1.50 Å resolution, a structural homolog of Δ5-3-ketosteroid isomerase
    Cherney, Maia M.
    Garen, Craig R.
    James, Michael N. G.
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2008, 1784 (11): : 1625 - 1632
  • [22] Rv2037c, a stress induced conserved hypothetical protein of Mycobacterium tuberculosis, is a phospholipase: Role in cell wall modulation and intracellular survival
    Kumari, Bandana
    Saini, Varinder
    Kaur, Jasbinder
    Kaur, Jagdeep
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 153 : 817 - 835
  • [23] Solution structure of Rv0569, potent hypoxic signal transduction protein, from Mycobacterium tuberculosis
    Kim, Won-Je
    Son, Woo Sung
    Ahn, Do-Hwan
    Im, Hookang
    Ahn, Hee-Chul
    Lee, Bong-Jin
    TUBERCULOSIS, 2014, 94 (01) : 43 - 50
  • [24] Biophysical and biochemical characterization of Rv3405c, a tetracycline repressor protein from Mycobacterium tuberculosis
    Gopalan, Akilandeswari
    Bhagavat, Raghu
    Chandra, Nagasuma
    Subbarao, Savithri Handanahal
    Raja, Alamelu
    Bethunaickan, Ramalingam
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 496 (03) : 799 - 805
  • [25] Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c
    Wang, Lu
    Li, Jun
    Wang, Xiangxi
    Liu, Wu
    Zhang, Xuejun C.
    Li, Xuemei
    Rao, Zihe
    PROTEIN & CELL, 2013, 4 (08) : 628 - 640
  • [26] The structure of Rv2372c identifies an RsmE-like methyltransferase from Mycobacterium tuberculosis
    Kumar, Atul
    Kumar, Santosh
    Taneja, Bhupesh
    ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2014, 70 : 821 - 832
  • [27] The crystal structure of an essential high-temperature requirement protein HtrA1 (Rv1223) from Mycobacterium tuberculosis reveals its unique features
    Singh, Khundrakpam Herojit
    Yadav, Savita
    Kumar, Deepak
    Biswal, Bichitra Kumar
    ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2018, 74 : 906 - 921
  • [28] Structure-function insights into elusive Mycobacterium tuberculosis protein Rv1916
    Antil, Monika
    Sharma, Jyoti
    Brissonnet, Yoan
    Choudhary, Monika
    Gouin, Sebastien
    Gupta, Vibha
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 141 : 927 - +
  • [29] Insights Into a New Zn Binding Protein Rv2699c in Mycobacterium tuberculosis
    Cartwright, Kaitlin
    Zhang, Limei
    Wong, Huey-Xian
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 300 (03) : S623 - S623
  • [30] Crystal structure and biochemical study on argininosuccinate lyase from Mycobacterium tuberculosis
    Chen, Xiaobo
    Chen, Jiayue
    Zhang, Wei
    Wang, Huiying
    Liu, Xiang
    Zhou, Weihong
    Yang, Haitao
    Rao, Zihe
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 510 (01) : 116 - 121
12345