A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017

被引：15

作者：

Kuebler, Wolfgang M. ^{[1
,2
,3
,4
]}

Nicolls, Mark R. ^{[5
]}

Olschewski, Andrea ^{[6
,14
]}

Abe, Kohtaro ^{[7
]}

Rabinovitch, Marlene ^{[8
]}

Stewart, Duncan ^{[9
]}

Chan, Stephen Y. ^{[10
,11
]}

Morrell, Nicholas W. ^{[12
]}

Archer, Stephen L. ^{[13
]}

Spiekerkoetter, Edda ^{[5
]}

机构：

[1] Charite Univ Med Berlin, Inst Physiol, Berlin, Germany

[2] Keenan Res Ctr Biomed Sci St Michaels, Toronto, ON, Canada

[3] Univ Toronto, Dept Surg, Toronto, ON, Canada

[4] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[5] Stanford Univ, Dept Med, Wall Ctr Pulm Vasc Dis, Div Pulm & Crit Care,Dept Cardiovasc Inst, Stanford, CA 94305 USA

[6] Med Univ Graz, Ludwig Boltzmann Inst, Lung Vasc Res, Graz, Austria

[7] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka, Fukuoka, Japan

[8] Stanford Univ, Dept Pediat, Sch Med, Div Cardiol, Stanford, CA 94305 USA

[9] Ottawa Hosp Res Inst, Div Cardiol, Dept Med, Ottawa, ON, Canada

[10] Univ Pittsburgh, Sch Med, Dept Med,Div Cardiol, Ctr Pulm Vasc Biol & Med,Pittsburgh Heart Lung Bl, Pittsburgh, PA 15213 USA

[11] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[12] Univ Cambridge, Sch Clin Med, Dept Med, Div Resp Med, Cambridge, England

[13] Queens Univ, Dept Med, Kingston, ON, Canada

[14] Johannes Kepler Univ Linz, Med Rectorate, Linz, Austria

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2018年 / 315卷 / 04期

基金：

加拿大健康研究院;

关键词：

PULMONARY ARTERIAL-HYPERTENSION; TO-MESENCHYMAL TRANSITION; CONGENITAL HEART-DISEASE; SMOOTH-MUSCLE-CELLS; II RECEPTOR; BLOOD-FLOW; BMPR-II; LYMPHORETICULAR DISEASE; EXTRACELLULAR-MATRIX; ENDOTHELIAL-CELLS;

D O I：

10.1152/ajplung.00150.2018

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took place at the American Thoracic Society Conference in May 2017. Leaders in the field of PAH research discussed the importance of the immune system, the role of hemodynamic stress and endothelial apoptosis, as well as bone morphogenetic protein receptor-2 signaling in PAH pathogenesis. Whereas this summary does not intend to resolve obvious conflicts in opinion, we hope that the presented arguments entice further discussions and draw a new generation of enthusiastic researchers into this vibrant field of science to bridge existing gaps for a better understanding and therapy of this fatal disease.

引用

页码：L502 / L516

页数：15

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