Neutrophil priming as a risk factor for surgical site infection in patients with colon cancer treated by laparoscopic surgery

被引：3

作者：

Toiyama, Yuji ^{[1
]}

Okugawa, Yoshinaga ^{[1
]}

Shimura, Tadanobu ^{[1
]}

Ide, Shozo ^{[1
]}

Yasuda, Hiromi ^{[1
]}

Fujikawa, Hiroyuki ^{[1
]}

Okita, Yoshiki ^{[1
]}

Yokoe, Takeshi ^{[1
]}

Hiro, Junichiro ^{[1
]}

Ohi, Masaki ^{[1
]}

Kusunoki, Masato ^{[1
]}

机构：

[1] Mie Univ, Dept Gastrointestinal & Pediat Surg, Div Reparat Med, Inst Life Sci,Grad Sch Med, Tsu, Mie 5148507, Japan

来源：

BMC SURGERY | 2020年 / 20卷 / 01期

关键词：

Neutrophil; Surgical site infection; Anastomotic leakage; Colon Cancer; PREVENTION; COMPLICATIONS; PROPHYLAXIS; OPERATIONS; RESECTION;

D O I：

10.1186/s12893-019-0674-6

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background The purpose of this study is to identify perioperative marker predicting postoperative surgical site infection (SSI) including with anastomotic leakage (AL) in curative colon cancer patients, laparoscopically. Methods In total, 135 colon cancer patients (stage I-III) undergoing curative laparoscopic surgery between January 2004 and December 2013 were enrolled in this study. We collected data on clinicopathological factors, laboratory data on pre and postoperative day 3 (POD3) and tumor markers levels to assess the relation to surgical site infection (SSI) including with anastomotic leakage (AL). Results SSI and AL occurred in 16 cases (5.6%) and 4 cases (3%), respectively. SSI and AL were not association with clinicopathological factors. Within laboratory data and tumor markers preoperatively, high neutrophil counts were significantly associated with SSI (P < 0.05) and AL (P < 0.01), respectively. Area under curves (AUC) of SSI and AL were 0.656 and 0.854, respectively. In addition, high neutrophil counts on POD3 also were significantly associated with SSI (P < 0.01) and AL (P < 0.01), respectively. Area under curves (AUC) of SSI and AL were 0.747 and 0.832, respectively. Conclusion Neutrophil count on pre and POD3 are potentially valuable indicators of SSI including with AL in colon cancer patients undergoing curative surgery laparoscopically.

引用

页数：8

共 23 条

[1] Morbidity and mortality associated with surgical site infections:: results from the 1997-1999 INCISO surveillance [J].