Association between CRP polymorphisms and susceptibility to the diabetic nephropathy; A case-control study

被引：0
|
作者：
Ghanbari, Molud [1 ,5 ]
Miladipour, Amir Hossein [1 ]
Ghaderian, Sayyed Mohammad Hossein [2 ]
Fazeli, Zahra [3 ]
Rajabi, Shirin [4 ]
Rajabibazl, Masoumeh [5 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Fac Med, Chron Kidney Dis Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Fac Med, Dept Med Genet, Tehran, Iran
[4] Univ Tehran, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Fac Med, Urol & Nephrol Res Ctr, Tehran, Iran
来源：
META GENE | 2022年 / 31卷
关键词：
Diabetic nephropathy; CRP gene; rs2794521; rs1800947; Polymorphism; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; GENE POLYMORPHISMS; RISK; MICROALBUMINURIA; INFLAMMATION; MELLITUS;
D O I：
10.1016/j.mgene.2021.101009
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Diabetic nephropathy (DN) was considered as the major cause of end-stage renal disease (ESRD) with the high mortality rate in the affected patients. Patients with DN are at high risk of death from cardiovascular diseases. C-reactive protein (CRP) gene has been known to be effective in the pathogenesis of renal and cardiovascular disease. The aim of the present study was to investigate the association between two CRP polymorphisms, rs2794521 and rs1800947, and risk of DN. Seventy-five patients with DN, fifty patients with diabetic mellitus and fifty healthy controls were enrolled. The genotyping of rs2794521 and rs1800947 were done by using PCR-RFLP. The analysis of the results indicated that rs2794521 was significantly associated with susceptibility to DN but no diabetic mellitus. No association was observed between rs1800947 and the DN risk. The obtained data suggested that rs2794521 may play a role in the etiology of DN.
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页数：5
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