Association between CRP polymorphisms and susceptibility to the diabetic nephropathy; A case-control study

Diabetic nephropathy (DN) was considered as the major cause of end-stage renal disease (ESRD) with the high mortality rate in the affected patients. Patients with DN are at high risk of death from cardiovascular diseases. C-reactive protein (CRP) gene has been known to be effective in the pathogenesis of renal and cardiovascular disease. The aim of the present study was to investigate the association between two CRP polymorphisms, rs2794521 and rs1800947, and risk of DN. Seventy-five patients with DN, fifty patients with diabetic mellitus and fifty healthy controls were enrolled. The genotyping of rs2794521 and rs1800947 were done by using PCR-RFLP. The analysis of the results indicated that rs2794521 was significantly associated with susceptibility to DN but no diabetic mellitus. No association was observed between rs1800947 and the DN risk. The obtained data suggested that rs2794521 may play a role in the etiology of DN.